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Literature DB >> 25555684

Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.

Abstract

As an intracellular Ca(2+) release channel at the endoplasmic reticulum membrane, the ubiquitous inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) plays a crucial role in the generation, propagation and regulation of intracellular Ca(2+) signals that regulate numerous physiological and pathophysiological processes. This review provides a concise account of the fundamental single-channel properties of the InsP3R channel: its conductance properties and its regulation by InsP3 and Ca(2+), its physiological ligands, studied using nuclear patch clamp electrophysiology.

Entities: CellLine Chemical Disease Gene Species

Keywords: Calcium signal; Endoplasmic reticulum; Inositol 1,4,5-trisphosphate receptor; Intracellular calcium; Ion channel; Patch clamp electrophysiology

Mesh：

Substances：

Year: 2014 PMID： 25555684 PMCID： PMC4458407 DOI： 10.1016/j.ceca.2014.12.008

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

79 in total

1. Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels.

Authors: Horia Vais; Adam P Siebert; Zhongming Ma; Marisabel Fernández-Mongil; J Kevin Foskett; Don-On Daniel Mak
Journal: Biophys J Date: 2010-07-21 Impact factor: 4.033

2. Counting functional inositol 1,4,5-trisphosphate receptors into the plasma membrane.

Authors: Olivier Dellis; Ana M Rossi; Skarlatos G Dedos; Colin W Taylor
Journal: J Biol Chem Date: 2007-11-13 Impact factor: 5.157

3. Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study.

Authors: Dirk Gillespie; Michael Fill
Journal: Biophys J Date: 2008-07-11 Impact factor: 4.033

4. Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

Authors: Kamil J Alzayady; Larry E Wagner; Rahul Chandrasekhar; Alina Monteagudo; Ronald Godiska; Gregory G Tall; Suresh K Joseph; David I Yule
Journal: J Biol Chem Date: 2013-08-16 Impact factor: 5.157

5. Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.

Authors: D O Mak; S McBride; J K Foskett
Journal: Proc Natl Acad Sci U S A Date: 1998-12-22 Impact factor: 11.205

6. Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels.

Authors: J Ramos-Franco; M Fill; G A Mignery
Journal: Biophys J Date: 1998-08 Impact factor: 4.033

7. Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types.

Authors: R J Wojcikiewicz
Journal: J Biol Chem Date: 1995-05-12 Impact factor: 5.157

8. Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

Authors: Miwako Iwai; Takayuki Michikawa; Ivan Bosanac; Mitsuhiko Ikura; Katsuhiko Mikoshiba
Journal: J Biol Chem Date: 2007-02-27 Impact factor: 5.157

9. Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers.

Authors: Jianwei Shuai; John E Pearson; Ian Parker
Journal: Biophys J Date: 2008-07-18 Impact factor: 4.033

10. Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.

Authors: Horia Vais; J Kevin Foskett; Ghanim Ullah; John E Pearson; Don-On Daniel Mak
Journal: J Gen Physiol Date: 2012-11-12 Impact factor: 4.086

33 in total

Review 1. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Authors: Nathan R Tykocki; Erika M Boerman; William F Jackson
Journal: Compr Physiol Date: 2017-03-16 Impact factor: 9.090

2. All three IP₃ receptor isoforms generate Ca²⁺ puffs that display similar characteristics.

Authors: Jeffrey T Lock; Kamil J Alzayady; David I Yule; Ian Parker
Journal: Sci Signal Date: 2018-12-18 Impact factor: 8.192

3. Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.

Authors: Jun Yang; Horia Vais; Wenen Gu; J Kevin Foskett
Journal: Proc Natl Acad Sci U S A Date: 2016-03-14 Impact factor: 11.205

4. Emergence of ion channel modal gating from independent subunit kinetics.

Authors: Brendan A Bicknell; Geoffrey J Goodhill
Journal: Proc Natl Acad Sci U S A Date: 2016-08-22 Impact factor: 11.205

Review 5. Physiology of Astroglia.

Authors: Alexei Verkhratsky; Maiken Nedergaard
Journal: Physiol Rev Date: 2018-01-01 Impact factor: 37.312

Review 6. Targeting Bcl-2-IP₃ receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Authors: Clark W Distelhorst
Journal: Biochim Biophys Acta Mol Cell Res Date: 2018-07-25 Impact factor: 4.739

Review 10. ROS and intracellular ion channels.

Authors: Kirill Kiselyov; Shmuel Muallem
Journal: Cell Calcium Date: 2016-03-11 Impact factor: 6.817

Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.

1. Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channels.

2. Counting functional inositol 1,4,5-trisphosphate receptors into the plasma membrane.

3. Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study.

4. Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

5. Inositol 1,4,5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition.

6. Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels.

7. Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types.

8. Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

9. Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers.

10. Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating.

Review 1. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

2. All three IP₃ receptor isoforms generate Ca²⁺ puffs that display similar characteristics.

3. Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.

4. Emergence of ion channel modal gating from independent subunit kinetics.

Review 5. Physiology of Astroglia.

Review 6. Targeting Bcl-2-IP₃ receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Review 7. Organellar channels and transporters.

Review 8. CRAC channels in secretory epithelial cell function and disease.

Review 9. Spatial-temporal patterning of Ca²⁺ signals by the subcellular distribution of IP₃ and IP₃ receptors.

Review 10. ROS and intracellular ion channels.

Review 1. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Review 5. Physiology of Astroglia.

Review 6. Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Review 7. Organellar channels and transporters.

Review 8. CRAC channels in secretory epithelial cell function and disease.

Review 9. Spatial-temporal patterning of Ca2+ signals by the subcellular distribution of IP3 and IP3 receptors.

Review 10. ROS and intracellular ion channels.

Review 6. Targeting Bcl-2-IP₃ receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

Review 9. Spatial-temporal patterning of Ca²⁺ signals by the subcellular distribution of IP₃ and IP₃ receptors.