Johanna Sjövall1, Benjamin Chua2, David Pryor3, Elizabeth Burmeister3, Matthew C Foote4, Benedict Panizza5, Bryan H Burmeister4, Sandro V Porceddu4. 1. Skane University Hospital, Department of ORL-Head and Neck Surgery, Clinical Sciences, Lund University, Sweden. 2. Princess Alexandra Hospital, Radiation Oncology, Brisbane, Queensland, Australia; Princess Alexandra Hospital, Department of Otolaryngology, Brisbane, Queensland, Australia. Electronic address: benjamin.chua@health.qld.gov.au. 3. Princess Alexandra Hospital, Radiation Oncology, Brisbane, Queensland, Australia. 4. Princess Alexandra Hospital, Radiation Oncology, Brisbane, Queensland, Australia; University of Queensland, St. Lucia, Queensland, Australia. 5. Princess Alexandra Hospital, Department of Otolaryngology, Brisbane, Queensland, Australia; University of Queensland, St. Lucia, Queensland, Australia.
Abstract
OBJECTIVES: The current study presents the long-term results from a study designed to evaluate a restaging positron emission tomography (PET) directed policy whereby neck dissections were omitted in all node positive head and neck squamous cell carcinoma (N+HNSCC) patients with PET-negative lymph nodes after definitive radiotherapy (RT), with or without chemotherapy. METHODS: A post-therapy nodal response assessment with PET and computed tomography (CT) was performed in patients who achieved a complete response at the primary site after definitive radiotherapy. Patients with PET-negative lymph nodes were observed regardless of residual CT abnormalities. RESULTS: One hundred and twelve patients, the majority of whom (83 patients, 74%) had oropharyngeal primaries, were treated on protocol. Median follow-up was 62months. Negative and positive predictive values for the restaging PET was 97.1% and 77.8% respectively, with only one patient who was PET-negative after treatment experiencing an isolated nodal relapse. CONCLUSION: PET-guided management of the neck following organ preservation therapy effectively spares neck dissections in patients with N+HNSCC without compromising isolated nodal control or overall survival. Crown
OBJECTIVES: The current study presents the long-term results from a study designed to evaluate a restaging positron emission tomography (PET) directed policy whereby neck dissections were omitted in all node positive head and neck squamous cell carcinoma (N+HNSCC) patients with PET-negative lymph nodes after definitive radiotherapy (RT), with or without chemotherapy. METHODS: A post-therapy nodal response assessment with PET and computed tomography (CT) was performed in patients who achieved a complete response at the primary site after definitive radiotherapy. Patients with PET-negative lymph nodes were observed regardless of residual CT abnormalities. RESULTS: One hundred and twelve patients, the majority of whom (83 patients, 74%) had oropharyngeal primaries, were treated on protocol. Median follow-up was 62months. Negative and positive predictive values for the restaging PET was 97.1% and 77.8% respectively, with only one patient who was PET-negative after treatment experiencing an isolated nodal relapse. CONCLUSION: PET-guided management of the neck following organ preservation therapy effectively spares neck dissections in patients with N+HNSCC without compromising isolated nodal control or overall survival. Crown
Authors: Johanna Sjövall; Ulrika Bitzén; Elisabeth Kjellén; Per Nilsson; Peter Wahlberg; Eva Brun Journal: Eur J Nucl Med Mol Imaging Date: 2015-10-02 Impact factor: 9.236
Authors: Ayse Tuba Kendi; David Brandon; Jeffrey Switchenko; Jeffery Trad Wadsworth; Mark W El-Deiry; Nabil F Saba; David M Schuster; Rathan M Subramaniam Journal: Am J Nucl Med Mol Imaging Date: 2017-09-01
Authors: R Maquieira; S K Haerle; G F Huber; A Soltermann; S R Haile; S J Stoeckli; Martina A Broglie Journal: Eur Arch Otorhinolaryngol Date: 2015-06-10 Impact factor: 2.503