Literature DB >> 25540902

The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond.

Darrick T Balu1, Joseph T Coyle2.   

Abstract

Schizophrenia is a severe psychiatric illness that is characterized by reduced cortical connectivity, for which the underlying biological and genetic causes are not well understood. Although the currently approved antipsychotic drug treatments, which primarily modulate dopaminergic function, are effective at reducing positive symptoms (i.e. delusions and hallucinations), they do little to improve the disabling cognitive and negative (i.e. anhedonia) symptoms of patients with schizophrenia. This review details the recent genetic and neurobiological findings that link N-methyl-D-aspartate receptor (NMDAR) hypofunction to the etiology of schizophrenia. It also highlights potential treatment strategies that augment NMDA receptor function to treat the synaptic deficits and cognitive impairments.
Copyright © 2014. Published by Elsevier Ltd.

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Year:  2014        PMID： 25540902      PMCID： PMC4805108          DOI： 10.1016/j.coph.2014.12.004

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  63 in total

1.  Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.

Authors:  Nicole C Allen; Sachin Bagade; Matthew B McQueen; John P A Ioannidis; Fotini K Kavvoura; Muin J Khoury; Rudolph E Tanzi; Lars Bertram
Journal:  Nat Genet       Date:  2008-07       Impact factor: 38.330

2.  On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress.

Authors:  R Lugo-Huitrón; T Blanco-Ayala; P Ugalde-Muñiz; P Carrillo-Mora; J Pedraza-Chaverrí; D Silva-Adaya; P D Maldonado; I Torres; E Pinzón; E Ortiz-Islas; T López; E García; B Pineda; M Torres-Ramos; A Santamaría; V Pérez-De La Cruz
Journal:  Neurotoxicol Teratol       Date:  2011-07-13       Impact factor: 3.763

3.  Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine.

Authors:  Jean-Pierre Mothet; Loredano Pollegioni; Gilles Ouanounou; Magalie Martineau; Philippe Fossier; Gérard Baux
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-30       Impact factor: 11.205

4.  D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.

Authors:  Jeffrey T Ehmsen; Ting Martin Ma; Hagit Sason; Dina Rosenberg; Tadashi Ogo; Shigeki Furuya; Solomon H Snyder; Herman Wolosker
Journal:  J Neurosci       Date:  2013-07-24       Impact factor: 6.167

5.  Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.

Authors:  H Wolosker; S Blackshaw; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

6.  The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.

Authors:  C Hilmas; E F Pereira; M Alkondon; A Rassoulpour; R Schwarcz; E X Albuquerque
Journal:  J Neurosci       Date:  2001-10-01       Impact factor: 6.167

7.  Increased cortical kynurenate content in schizophrenia.

Authors:  R Schwarcz; A Rassoulpour; H Q Wu; D Medoff; C A Tamminga; R C Roberts
Journal:  Biol Psychiatry       Date:  2001-10-01       Impact factor: 13.382

8.  Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity.

Authors:  Dina Rosenberg; Samar Artoul; Adi C Segal; Goren Kolodney; Inna Radzishevsky; Elena Dikopoltsev; Veronika N Foltyn; Ran Inoue; Hisashi Mori; Jean-Marie Billard; Herman Wolosker
Journal:  J Neurosci       Date:  2013-02-20       Impact factor: 6.167

9.  Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention.

Authors:  D Quartermain; J Mower; M F Rafferty; R L Herting; T H Lanthorn
Journal:  Eur J Pharmacol       Date:  1994-05-12       Impact factor: 4.432

10.  Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging.

Authors:  A Hashimoto; T Nishikawa; T Oka; K Takahashi
Journal:  J Neurochem       Date:  1993-02       Impact factor: 5.372
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  77 in total

1.  Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia.

Authors:  Ariel A Jacobi; Sarah Halawani; David R Lynch; Hong Lin
Journal:  Neurosci Lett       Date:  2018-11-01       Impact factor: 3.046

2.  Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia.

Authors:  Pantea Moghimi; Nathalia Torres Jimenez; Linda K McLoon; Theoden I Netoff; Michael S Lee; Angus MacDonald; Robert F Miller
Journal:  Schizophr Res       Date:  2019-10-12       Impact factor: 4.939

Review 3.  Auditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function.

Authors:  Joshua T Kantrowitz; Neal R Swerdlow; Walter Dunn; Sophia Vinogradov
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2018-02-22

4.  Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features.

Authors:  Suyan Li; Yota Uno; Uwe Rudolph; Johanna Cobb; Jing Liu; Thea Anderson; Deborah Levy; Darrick T Balu; Joseph T Coyle
Journal:  Biochem Pharmacol       Date:  2018-01-03       Impact factor: 5.858

Review 5.  Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder.

Authors:  Trevor Archer; Richard M Kostrzewa
Journal:  Neurotox Res       Date:  2015-07-15       Impact factor: 3.911

Review 6.  Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.

Authors:  Maria R Dauvermann; Graham Lee; Neil Dawson
Journal:  Br J Pharmacol       Date:  2017-08-11       Impact factor: 8.739

7.  Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.

Authors:  Sayuri Ishiwata; Asami Umino; Darrick T Balu; Joseph T Coyle; Toru Nishikawa
Journal:  J Neural Transm (Vienna)       Date:  2015-03-18       Impact factor: 3.575

8.  A systematic meta-analysis of the association of Neuregulin 1 (NRG1), D-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia.

Authors:  Vinita Jagannath; Miriam Gerstenberg; Christoph U Correll; Susanne Walitza; Edna Grünblatt
Journal:  J Neural Transm (Vienna)       Date:  2017-09-01       Impact factor: 3.575

Review 9.  History of the Concept of Disconnectivity in Schizophrenia.

Authors:  Joseph T Coyle; Darrick T Balu; Matthew D Puhl; Glenn T Konopaske
Journal:  Harv Rev Psychiatry       Date:  2016 Mar-Apr       Impact factor: 3.732

10.  Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.

Authors:  M J Kim; J Biag; D M Fass; M C Lewis; Q Zhang; M Fleishman; S P Gangwar; M Machius; M Fromer; S M Purcell; S A McCarroll; G Rudenko; R T Premont; E M Scolnick; S J Haggarty
Journal:  Mol Psychiatry       Date:  2016-07-26       Impact factor: 15.992
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