| Literature DB >> 8419554 |
A Hashimoto1, T Nishikawa, T Oka, K Takahashi.
Abstract
Recently, a substantial amount of free D-serine has been demonstrated in rat brain, although it has long been presumed that D-amino acids are uncommon in mammals. The anatomical distribution and age-related changes in endogenous D-serine have been examined here to obtain insight into its physiological functions. Free D-serine exclusively occurs in brains, with a persistent high content from birth to at least 86 postnatal weeks. The patterns of the regional variations and the postnatal changes in brain D-serine are closely correlated with those of the N-methyl-D-aspartate (NMDA)-type excitatory amino acid receptor. Because D-serine potentiates NMDA receptor-mediated transmission by selective stimulation of the strychnine-insensitive glycine site of the NMDA receptor, it is proposed that D-serine is a novel candidate as an intrinsic ligand for the glycine site in mammalian brain.Entities:
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Year: 1993 PMID： 8419554 DOI： 10.1111/j.1471-4159.1993.tb03219.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372