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Literature DB >> 25782690

Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.

Sayuri Ishiwata¹, Asami Umino, Darrick T Balu, Joseph T Coyle, Toru Nishikawa.

Abstract

In the hippocampus of mice lacking the gene for serine racemase (SR), a D-serine synthesizing enzyme, in the CaMKIIα-expressing neurons, we observed a significant decrease in the extracellular concentration of D-serine, a coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), and NMDAR hypofunction as revealed by diminished extracellular taurine concentrations after an intra-hippocampal NMDA infusion when compared to the wild type controls. Therefore, the neuronal SR could regulate the extracellular D-serine signaling responsible for NMDAR activation in the hippocampus.

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Year: 2015 PMID： 25782690 PMCID： PMC4805119 DOI： 10.1007/s00702-015-1388-2

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

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