Literature DB >> 25530918

Role of Shiga/Vero toxins in pathogenesis.

Fumiko Obata1, Tom Obrig1.   

Abstract

Shiga toxin (Stx) is the primary cause of severe host responses including renal and central nervous system (CNS) disease in Shiga toxin-producing E. coli (STEC) infections. The interaction of Stx with different eukaryotic cell types is described. Host responses to Stx and bacterial lipopolysaccharide (LPS) are compared as related to the features of the STEC-associated Hemolytic Uremic Syndrome (HUS). Data derived from animal models of HUS and CNS disease, in vivo, and eukaryotic cells, in vitro, are evaluated in relation to HUS disease of humans.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25530918      PMCID： PMC4270003          DOI： 10.1128/microbiolspec.EHEC-0005-2013

Source DB:  PubMed          Journal:  Microbiol Spectr        ISSN： 2165-0497


  70 in total

1.  Toxicity of Shiga toxin 1 in the central nervous system of rabbits.

Authors:  J Fujii; Y Kinoshita; T Yutsudo; H Taniguchi; T Obrig; S I Yoshida
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

2.  Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome.

Authors:  Tiffany R Keepers; Lisa K Gross; Tom G Obrig
Journal:  Infect Immun       Date:  2007-01-12       Impact factor: 3.441

3.  Intracerebroventricular Shiga toxin 2 increases the expression of its receptor globotriaosylceramide and causes dendritic abnormalities.

Authors:  Carla Tironi-Farinati; C Fabián Loidl; Javier Boccoli; Yanil Parma; Mariano E Fernandez-Miyakawa; Jorge Goldstein
Journal:  J Neuroimmunol       Date:  2010-03-27       Impact factor: 3.478

4.  Shiga toxin induces medullary tubular injury in isolated perfused rat kidneys.

Authors:  O Shibolet; A Shina; S Rosen; T G Cleary; M Brezis; S Ashkenazi
Journal:  FEMS Immunol Med Microbiol       Date:  1997-05

5.  Intraperitoneal administration of Shiga toxin 2 induced neuronal alterations and reduced the expression levels of aquaporin 1 and aquaporin 4 in rat brain.

Authors:  María Soledad Lucero; Federico Mirarchi; Jorge Goldstein; Claudia Silberstein
Journal:  Microb Pathog       Date:  2012-05-17       Impact factor: 3.738

6.  Acute renal tubular necrosis and death of mice orally infected with Escherichia coli strains that produce Shiga-like toxin type II.

Authors:  E A Wadolkowski; L M Sung; J A Burris; J E Samuel; A D O'Brien
Journal:  Infect Immun       Date:  1990-12       Impact factor: 3.441

7.  Shiga toxin binding to isolated porcine tissues and peripheral blood leukocytes.

Authors:  Kellie R K Winter; William C Stoffregen; Evelyn A Dean-Nystrom
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

8.  Shiga toxin binds to activated platelets.

Authors:  S A Ghosh; R K Polanowska-Grabowska; J Fujii; T Obrig; A R L Gear
Journal:  J Thromb Haemost       Date:  2004-03       Impact factor: 5.824

9.  Shiga toxin 1 elicits diverse biologic responses in mesangial cells.

Authors:  M Simon; T G Cleary; J D Hernandez; H E Abboud
Journal:  Kidney Int       Date:  1998-10       Impact factor: 10.612

10.  Investigation of encephalopathy caused by Shiga toxin 2c-producing Escherichia coli infection in mice.

Authors:  Muhammad Yunus Amran; Jun Fujii; Satoshi O Suzuki; Glynis L Kolling; Sharon Y A M Villanueva; Mosaburo Kainuma; Hideyuki Kobayashi; Hideko Kameyama; Shin-ichi Yoshida
Journal:  PLoS One       Date:  2013-03-13       Impact factor: 3.240
View more
  10 in total

Review 1.  Overview and Historical Perspectives.

Authors:  James B Kaper; Alison D O'Brien
Journal:  Microbiol Spectr       Date:  2014-12

2.  Cognitive Deficits Found in a Pro-inflammatory State are Independent of ERK1/2 Signaling in the Murine Brain Hippocampus Treated with Shiga Toxin 2 from Enterohemorrhagic Escherichia coli.

Authors:  Clara Berdasco; Alipio Pinto; Mariano G Blake; Fernando Correa; Nadia A Longo Carbajosa; Ana B Celi; Patricia A Geoghegan; Adriana Cangelosi; Myriam Nuñez; Mariela M Gironacci; Jorge Goldstein
Journal:  Cell Mol Neurobiol       Date:  2022-10-13       Impact factor: 4.231

Review 3.  Pathogenic role of inflammatory response during Shiga toxin-associated hemolytic uremic syndrome (HUS).

Authors:  Ramon Alfonso Exeni; Romina Jimena Fernandez-Brando; Adriana Patricia Santiago; Gabriela Alejandra Fiorentino; Andrea Mariana Exeni; Maria Victoria Ramos; Marina Sandra Palermo
Journal:  Pediatr Nephrol       Date:  2018-01-25       Impact factor: 3.714

4.  ppGpp and cytotoxicity diversity in Shiga toxin-producing Escherichia coli (STEC) isolates.

Authors:  A E Stella; D Luz; R M F Piazza; B Spira
Journal:  Epidemiol Infect       Date:  2017-06-07       Impact factor: 4.434

5.  A Topographical Atlas of Shiga Toxin 2e Receptor Distribution in the Tissues of Weaned Piglets.

Authors:  Daniel Steil; Robert Bonse; Iris Meisen; Gottfried Pohlentz; German Vallejo; Helge Karch; Johannes Müthing
Journal:  Toxins (Basel)       Date:  2016-11-30       Impact factor: 4.546

6.  Efficacy of Urtoxazumab (TMA-15 Humanized Monoclonal Antibody Specific for Shiga Toxin 2) Against Post-Diarrheal Neurological Sequelae Caused by Escherichia coli O157:H7 Infection in the Neonatal Gnotobiotic Piglet Model.

Authors:  Rodney A Moxley; David H Francis; Mizuho Tamura; David B Marx; Kristina Santiago-Mateo; Mojun Zhao
Journal:  Toxins (Basel)       Date:  2017-01-26       Impact factor: 4.546

7.  LPS-primed CD11b+ leukocytes serve as an effective carrier of Shiga toxin 2 to cause hemolytic uremic syndrome in mice.

Authors:  Shuo Niu; John Paluszynski; Zhen Bian; Lei Shi; Koby Kidder; Yuan Liu
Journal:  Sci Rep       Date:  2018-03-05       Impact factor: 4.379

8.  Shiga toxin type-2 (Stx2) induces glutamate release via phosphoinositide 3-kinase (PI3K) pathway in murine neurons.

Authors:  Fumiko Obata; Lauren M Hippler; Progyaparamita Saha; Dakshina M Jandhyala; Olga S Latinovic
Journal:  Front Mol Neurosci       Date:  2015-07-14       Impact factor: 5.639

Review 9.  Valid Presumption of Shiga Toxin-Mediated Damage of Developing Erythrocytes in EHEC-Associated Hemolytic Uremic Syndrome.

Authors:  Johanna Detzner; Gottfried Pohlentz; Johannes Müthing
Journal:  Toxins (Basel)       Date:  2020-06-04       Impact factor: 4.546

10.  The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli.

Authors:  Patricia B Lodato
Journal:  Sci Rep       Date:  2021-09-15       Impact factor: 4.379
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.