Literature DB >> 11553604

Toxicity of Shiga toxin 1 in the central nervous system of rabbits.

J Fujii1, Y Kinoshita, T Yutsudo, H Taniguchi, T Obrig, S I Yoshida.   

Abstract

The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

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Year:  2001        PMID： 11553604      PMCID： PMC98795          DOI： 10.1128/IAI.69.10.6545-6548.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  18 in total

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Authors:  M Yoh; E K Frimpong; T Honda
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2.  Clinical and pathological aspects of central nervous system involvement in the haemolytic uraemic syndrome.

Authors:  J C Rooney; R M Anderson; I J Hopkins
Journal:  Aust Paediatr J       Date:  1971-03

3.  Brainstem mechanisms of autonomic dysfunction in encephalopathy-associated Shiga toxin 2 intoxication.

Authors:  Y Yamada; J Fujii; Y Murasato; T Nakamura; Y Hayashida; Y Kinoshita; T Yutsudo; T Matsumoto; S Yoshida
Journal:  Ann Neurol       Date:  1999-06       Impact factor: 10.422

4.  Properties of strains of Escherichia coli belonging to serogroup O157 with special reference to production of Vero cytotoxins VT1 and VT2.

Authors:  S M Scotland; G A Willshaw; H R Smith; B Rowe
Journal:  Epidemiol Infect       Date:  1987-12       Impact factor: 2.451

5.  Massive outbreak of Escherichia coli O157:H7 infection in schoolchildren in Sakai City, Japan, associated with consumption of white radish sprouts.

Authors:  H Michino; K Araki; S Minami; S Takaya; N Sakai; M Miyazaki; A Ono; H Yanagawa
Journal:  Am J Epidemiol       Date:  1999-10-15       Impact factor: 4.897

6.  Magnetic resonance imaging and histopathological study of brain lesions in rabbits given intravenous verotoxin 2.

Authors:  J Fujii; Y Kinoshita; T Kita; A Higure; T Takeda; N Tanaka; S Yoshida
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

7.  The importance of nonrenal involvement in hemolytic-uremic syndrome.

Authors:  K Upadhyaya; K Barwick; M Fishaut; M Kashgarian; N J Siegel
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8.  Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools.

Authors:  M A Karmali; B T Steele; M Petric; C Lim
Journal:  Lancet       Date:  1983-03-19       Impact factor: 79.321

9.  Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro.

Authors:  C A Lingwood; H Law; S Richardson; M Petric; J L Brunton; S De Grandis; M Karmali
Journal:  J Biol Chem       Date:  1987-06-25       Impact factor: 5.157

10.  Hemorrhagic colitis associated with a rare Escherichia coli serotype.

Authors:  L W Riley; R S Remis; S D Helgerson; H B McGee; J G Wells; B R Davis; R J Hebert; E S Olcott; L M Johnson; N T Hargrett; P A Blake; M L Cohen
Journal:  N Engl J Med       Date:  1983-03-24       Impact factor: 91.245
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  6 in total

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Review 2.  Role of Shiga/Vero toxins in pathogenesis.

Authors:  Fumiko Obata; Tom Obrig
Journal:  Microbiol Spectr       Date:  2014-06

3.  Effect of globotriaosyl ceramide fatty acid alpha-hydroxylation on the binding by verotoxin 1 and verotoxin 2.

Authors:  Beth Binnington; Daniel Lingwood; Anita Nutikka; Clifford A Lingwood
Journal:  Neurochem Res       Date:  2002-08       Impact factor: 3.996

4.  Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody.

Authors:  Kristin A D Sauter; Angela R Melton-Celsa; Kay Larkin; Megan L Troxell; Alison D O'Brien; Bruce E Magun
Journal:  Infect Immun       Date:  2008-08-11       Impact factor: 3.441

5.  Development of an experimental hemolytic uremic syndrome in rats.

Authors:  Elsa Zotta; Nestor Lago; Federico Ochoa; Horacio A Repetto; Cristina Ibarra
Journal:  Pediatr Nephrol       Date:  2008-02-06       Impact factor: 3.714

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Authors:  Verónica I Landoni; Pablo Schierloh; Marcelo de Campos Nebel; Gabriela C Fernández; Cecilia Calatayud; María J Lapponi; Martín A Isturiz
Journal:  PLoS Pathog       Date:  2012-03-29       Impact factor: 6.823
  6 in total

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