Literature DB >> 103141

1-phenyl-3-pyrazolidone: an inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and platelets.

G J Blackwell, R J Flower.   

Abstract

1-phenyl-3-pyrazolidone (phenidone) is a commercially available reagent used in the photographic industry. When tested as an inhibitor of arachidonic acid metabolsim in platelets and lungs it was found to be effective against both the cyclo-oxygenase and lipoxygenase pathways. It is suggested that this compound may be a useful pharmacological tool.

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Year:  1978        PMID： 103141     DOI： 10.1016/0090-6980(78)90220-4

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  23 in total

1.  The effects of drugs on leucocyte changes following the injection of antigen into the peritoneal cavities of actively sensitised rats.

Authors:  B A Spicer; S M Laycock; H Smith
Journal:  Agents Actions       Date:  1986-03

2.  Mechanism of action of some inhibitors of endothelium-derived relaxing factor.

Authors:  S Moncada; R M Palmer; R J Gryglewski
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

3.  The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.

Authors:  W Kreutner; J Sherwood; C Rizzo
Journal:  Agents Actions       Date:  1989-11

4.  Interactions of a variety of lipoxygenase inhibitors with a supplementary binding site on soybean lipoxygenase.

Authors:  J Baumann; G Wurm; I Baumann
Journal:  Agents Actions       Date:  1985-03

5.  The pharmacology of arachidonic acid-induced rat PMN leukocyte infiltration.

Authors:  M J DiMartino; C E Wolff; G K Campbell; N Hanna
Journal:  Agents Actions       Date:  1989-06

6.  Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products.

Authors:  F R DeRubertis; P A Craven; R Saito
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

7.  Pharmacological studies into cyclo-oxygenase, lipoxygenase and phospholipase in smooth muscle contraction in the isolated trachea.

Authors:  H W Mitchell
Journal:  Br J Pharmacol       Date:  1984-07       Impact factor: 8.739

8.  Differential effects of putative lipoxygenase inhibitors on arachidonic acid metabolism in cell-free and intact cell preparations.

Authors:  J Chang; M D Skowronek; M L Cherney; A J Lewis
Journal:  Inflammation       Date:  1984-06       Impact factor: 4.092

9.  An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig.

Authors:  W H Anderson; M O'Donnell; B A Simko; A F Welton
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

10.  Effect of inhibition of arachidonic acid metabolism on anaphylaxis of guinea pig lung strips.

Authors:  S S Yen; W Kreutner
Journal:  Agents Actions       Date:  1980-06
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