Literature DB >> 25511740

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.

Christopher Fung1, Pei Zhou1, Sonali Joyce1, Kerry Trent2, Jian-Min Yuan2, Jennifer R Grandis3, Joel L Weissfeld2, Marjorie Romkes4, Daniel E Weeks5, Ann Marie Egloff6.   

Abstract

EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Case–control study; Genetic polymorphism; Head and neck cancer risk; Nonsmoker; Tobacco-independent

Mesh：

Substances：

Year:  2014        PMID： 25511740      PMCID： PMC4295492          DOI： 10.1016/j.canlet.2014.12.008

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  54 in total

1.  Polymorphisms of the epidermal growth factor receptor (EGFR) and survival in patients with advanced cancer of the head and neck (HNSCC).

Authors:  Jan Stoehlmacher-Williams; Luise Obermann; Gerhard Ehninger; Eray Goekkurt
Journal:  Anticancer Res       Date:  2012-02       Impact factor: 2.480

Review 2.  PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription.

Authors:  David B Beck; Hisanobu Oda; Steven S Shen; Danny Reinberg
Journal:  Genes Dev       Date:  2012-02-15       Impact factor: 11.361

3.  Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.

Authors:  Sarah Wheeler; Doris R Siwak; Raymond Chai; Courtney LaValle; Raja R Seethala; Lin Wang; Kathleen Cieply; Carol Sherer; Corwin Joy; Gordon B Mills; Athanassios Argiris; Jill M Siegfried; Jennifer R Grandis; Ann Marie Egloff
Journal:  Clin Cancer Res       Date:  2012-02-20       Impact factor: 12.531

4.  The epidermal growth factor receptor conundrum.

Authors:  Jason A Wilken; Andre T Baron; Nita J Maihle
Journal:  Cancer       Date:  2010-12-14       Impact factor: 6.860

5.  Genome-wide association study of glioma and meta-analysis.

Authors:  Preetha Rajaraman; Beatrice S Melin; Zhaoming Wang; Roberta McKean-Cowdin; Dominique S Michaud; Sophia S Wang; Melissa Bondy; Richard Houlston; Robert B Jenkins; Margaret Wrensch; Meredith Yeager; Anders Ahlbom; Demetrius Albanes; Ulrika Andersson; Laura E Beane Freeman; Julie E Buring; Mary Ann Butler; Melissa Braganza; Tania Carreon; Maria Feychting; Sarah J Fleming; Susan M Gapstur; J Michael Gaziano; Graham G Giles; Goran Hallmans; Roger Henriksson; Judith Hoffman-Bolton; Peter D Inskip; Christoffer Johansen; Cari M Kitahara; Mark Lathrop; Chenwei Liu; Loic Le Marchand; Martha S Linet; Stefan Lonn; Ulrike Peters; Mark P Purdue; Nathaniel Rothman; Avima M Ruder; Marc Sanson; Howard D Sesso; Gianluca Severi; Xiao-Ou Shu; Matthias Simon; Meir Stampfer; Victoria L Stevens; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Wei Zheng; Paul Decker; Victor Enciso-Mora; Brooke Fridley; Yu-Tang Gao; Matthew Kosel; Daniel H Lachance; Ching Lau; Terri Rice; Anthony Swerdlow; Joseph L Wiemels; John K Wiencke; Sanjay Shete; Yong-Bing Xiang; Yuanyuan Xiao; Robert N Hoover; Joseph F Fraumeni; Nilanjan Chatterjee; Patricia Hartge; Stephen J Chanock
Journal:  Hum Genet       Date:  2012-08-11       Impact factor: 4.132

6.  Absence of activating mutations in the EGFR kinase domain in Spanish head and neck cancer patients.

Authors:  Y Lemos-González; M Páez de la Cadena; F J Rodríguez-Berrocal; A M Rodríguez-Piñeiro; E Pallas; D Valverde
Journal:  Tumour Biol       Date:  2007-10-26

7.  Annotation of functional variation in personal genomes using RegulomeDB.

Authors:  Alan P Boyle; Eurie L Hong; Manoj Hariharan; Yong Cheng; Marc A Schaub; Maya Kasowski; Konrad J Karczewski; Julie Park; Benjamin C Hitz; Shuai Weng; J Michael Cherry; Michael Snyder
Journal:  Genome Res       Date:  2012-09       Impact factor: 9.043

8.  ENCODE whole-genome data in the UCSC Genome Browser: update 2012.

Authors:  Kate R Rosenbloom; Timothy R Dreszer; Jeffrey C Long; Venkat S Malladi; Cricket A Sloan; Brian J Raney; Melissa S Cline; Donna Karolchik; Galt P Barber; Hiram Clawson; Mark Diekhans; Pauline A Fujita; Mary Goldman; Robert C Gravell; Rachel A Harte; Angie S Hinrichs; Vanessa M Kirkup; Robert M Kuhn; Katrina Learned; Morgan Maddren; Laurence R Meyer; Andy Pohl; Brooke Rhead; Matthew C Wong; Ann S Zweig; David Haussler; W James Kent
Journal:  Nucleic Acids Res       Date:  2011-11-09       Impact factor: 16.971

9.  Genetic variation in the EGFR gene and the risk of glioma in a Chinese Han population.

Authors:  Wu-Gang Hou; Wen-Bo Ai; Xiao-Guang Bai; Hai-Long Dong; Zhen Li; Yuan-Qiang Zhang; Li-Ze Xiong
Journal:  PLoS One       Date:  2012-05-25       Impact factor: 3.240
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  5 in total

1.  Association between EGFR polymorphisms and the risk of lung cancer.

Authors:  Changjiang Liu; Xiaorong Xu; Yufa Zhou
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

2.  The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer.

Authors:  Sinead Toomey; Stephen F Madden; Simon J Furney; Yue Fan; Mark McCormack; Carragh Stapleton; Mattia Cremona; Gianpiero L Cavalleri; Malgorzata Milewska; Naomi Elster; Aoife Carr; Joanna Fay; Elaine W Kay; Susan Kennedy; John Crown; William M Gallagher; Bryan T Hennessy; Alex J Eustace
Journal:  Oncotarget       Date:  2016-11-15

3.  The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population.

Authors:  Tzu-Hua Chen; Joh-Jong Huang; Hsiang-Ying Lee; Wei-Shyang Kung; Kuei-Hau Luo; Jia-Yi Lu; Hung-Yi Chuang
Journal:  Int J Environ Res Public Health       Date:  2021-08-25       Impact factor: 3.390

Review 4.  EGFR Mutations in Head and Neck Squamous Cell Carcinoma.

Authors:  Sindhu Nair; James A Bonner; Markus Bredel
Journal:  Int J Mol Sci       Date:  2022-03-30       Impact factor: 5.923

5.  The Association between Epidermal Growth Factor Receptor (EGFR) Gene Polymorphisms and Lung Cancer Risk.

Authors:  Nabil A Bashir; Entesar S Ragab; Omar F Khabour; Basheer Y Khassawneh; Mahmoud A Alfaqih; Jafar A Momani
Journal:  Biomolecules       Date:  2018-07-13
  5 in total

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