TARGET: The study aimed to investigate the role of epidermal growth factor receptor (EGFR) rs6965469 and rs763317 polymorphisms in the occurrence and development of lung cancer. METHODS: We used polymerase chain reaction-ligation detection reaction (PCR-LDR) method to detect the genotypes of EGFR rs6965469 and rs763317 polymorphisms and the data were analyzed by GeneMapper software. Odds ratios (ORs) with 95% confidence intervals (CIs) was calculated by χ(2) test to estimate the significance difference of genotype and allele frequencies in case and control groups. ORs and 95% CIs were adjusted by logistic regression analysis with age, gender, drinking and smoking. The genotypes distributions of control group were tested by Hardy-Weinberg equilibrium (HWE). RESULTS: The genotypes frequencies of controls for rs6965469 and rs763317 polymorphims were consistent with HWE. The distribution of rs6965469 TT genotype in two groups was significantly different (P<0.05) and TT genotype was associated with an increased risk of lung cancer (OR=6.92, 95% CI=1.33-36.00). AA genotype and A allele of rs763317 were also the susceptible factors of lung cancer. Individuals with AA genotype or A allele were more likely to suffer lung cancer (AA vs. GG: OR=7.20, 95% CI=1.33-39.07; A vs. G: OR=2.61, 95% CI=1.04-6.59). CONCLUSIONS: The EGFR rs6965469 and rs763317 polymorphisms may be risk factors for lung cancer.
TARGET: The study aimed to investigate the role of epidermal growth factor receptor (EGFR) rs6965469 and rs763317 polymorphisms in the occurrence and development of lung cancer. METHODS: We used polymerase chain reaction-ligation detection reaction (PCR-LDR) method to detect the genotypes of EGFRrs6965469 and rs763317 polymorphisms and the data were analyzed by GeneMapper software. Odds ratios (ORs) with 95% confidence intervals (CIs) was calculated by χ(2) test to estimate the significance difference of genotype and allele frequencies in case and control groups. ORs and 95% CIs were adjusted by logistic regression analysis with age, gender, drinking and smoking. The genotypes distributions of control group were tested by Hardy-Weinberg equilibrium (HWE). RESULTS: The genotypes frequencies of controls for rs6965469 and rs763317 polymorphims were consistent with HWE. The distribution of rs6965469 TT genotype in two groups was significantly different (P<0.05) and TT genotype was associated with an increased risk of lung cancer (OR=6.92, 95% CI=1.33-36.00). AA genotype and A allele of rs763317 were also the susceptible factors of lung cancer. Individuals with AA genotype or A allele were more likely to suffer lung cancer (AA vs. GG: OR=7.20, 95% CI=1.33-39.07; A vs. G: OR=2.61, 95% CI=1.04-6.59). CONCLUSIONS: The EGFRrs6965469 and rs763317 polymorphisms may be risk factors for lung cancer.
Authors: Ahmedin Jemal; Taylor Murray; Elizabeth Ward; Alicia Samuels; Ram C Tiwari; Asma Ghafoor; Eric J Feuer; Michael J Thun Journal: CA Cancer J Clin Date: 2005 Jan-Feb Impact factor: 508.702
Authors: G Motalleb; E Pourrahmat; S Najafi; A Rashki; A Yegane Moghadam; M Mazaheri; M Jahantigh; K Sabagh; N Sanadgol; S Najafi; R Talaee Journal: Indian J Cancer Date: 2014 July-September Impact factor: 1.224
Authors: Ibrahim O Alanazi; Jilani Purusottapatnam Shaik; Narasimha Reddy Parine; Nahla A Azzam; Othman Alharbi; Yousef M Hawsawi; Atif Abdulwahab A Oyouni; Osama M Al-Amer; Faisal Alzahrani; Majid A Almadi; Abdulrahman M Aljebreen; Mohammad Saud Alanazi; Zahid Khan Journal: J Oncol Date: 2021-10-21 Impact factor: 4.375