Literature DB >> 25506810

Synthesis of indazole motifs and their medicinal importance: an overview.

Digambar D Gaikwad1, Archana D Chapolikar2, Chandrashekhar G Devkate2, Khandu D Warad2, Amit P Tayade2, Rajendra P Pawar3, Abraham J Domb4.   

Abstract

Indazoles is an important class of heterocyclic compounds having a wide range of biological and pharmaceutical applications. There is enormous potential in the synthesis of novel heterocyclic systems to be used as building blocks for the next generation of pharmaceuticals as anti-bacterial, anti-depressant and anti-inflammatory. Fused aromatic 1H and 2H-indazoles are well recognized for anti-hypertensive and anti-cancer properties. The present review focuses on novel routes of their synthesis and various biological activities.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antipsychotic; Antiretroviral; Antitumor; Axitinib; Chronic pain; Narcotic

Mesh：

Substances：

Year:  2014        PMID： 25506810     DOI： 10.1016/j.ejmech.2014.11.029

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  22 in total

Review 1.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

2.  Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination.

Authors:  Areum Park; Kyu-Sung Jeong; Hyuk Lee; Hyunwoo Kim
Journal:  ACS Omega       Date:  2021-02-23

3.  Uniting Amide Synthesis and Activation by PIII/PV-Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines.

Authors:  Jeffrey M Lipshultz; Alexander T Radosevich
Journal:  J Am Chem Soc       Date:  2021-09-03       Impact factor: 16.383

4.  Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media.

Authors:  Hui-Jun Nie; An-Di Guo; Hai-Xia Lin; Xiao-Hua Chen
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

5.  Crystal structure of N-(1-acetyl-3-chloro-1H-indazol-6-yl)-4-meth-oxy-benzene-sulfonamide.

Authors:  Yassine Hakmaoui; El Mostapha Rakib; Ahmed Gamouh; Mohamed Saadi; Lahcen El Ammari
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-11-04

6.  Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction.

Authors:  Manjunatha Narayanarao; Lokesh Koodlur; Vijayakumar G Revanasiddappa; Subramanya Gopal; Susmita Kamila
Journal:  Beilstein J Org Chem       Date:  2016-12-29       Impact factor: 2.883

7.  Crystal structure of 3,6,6-trimethyl-4-oxo-1-(pyridin-2-yl)-4,5,6,7-tetra-hydro-1H-indazol-7-aminium chloride and its monohydrate.

Authors:  Anatoly Mishnev; Alvis Mengots; Māris Turks
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-11-24

8.  Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability.

Authors:  Marianna Fekete; Peter J Rayner; Gary G R Green; Simon B Duckett
Journal:  Magn Reson Chem       Date:  2017-06-20       Impact factor: 2.447

9.  Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine.

Authors:  Justin Y Wang; Kyoungmin Choi; Stephan J Zuend; Kailaskumar Borate; Harish Shinde; Roland Goetz; John F Hartwig
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-27       Impact factor: 15.336

10.  Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity.

Authors:  Vijaykumar D Nimbarte; Julia Wirmer-Bartoschek; Santosh L Gande; Islam Alshamleh; Marcel Seibert; Hamid Reza Nasiri; Frank Schnütgen; Hubert Serve; Harald Schwalbe
Journal:  ChemMedChem       Date:  2021-03-22       Impact factor: 3.466
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