Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Revealing the world of RNA interference.

Literature DB >> 15372040

Revealing the world of RNA interference.

Abstract

The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.

Mesh：

Substances：
RNA, Double-Stranded

Year: 2004 PMID： 15372040 DOI： 10.1038/nature02872

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
Cited

282 in total

1. SHAPE-directed discovery of potent shRNA inhibitors of HIV-1.

Authors: Justin T Low; Stefanie A Knoepfel; Joseph M Watts; Olivier ter Brake; Ben Berkhout; Kevin M Weeks
Journal: Mol Ther Date: 2012-02-07 Impact factor: 11.454

2. Thermodynamic and kinetic analysis of an RNA kissing interaction and its resolution into an extended duplex.

Authors: Nilshad Salim; Rajan Lamichhane; Rui Zhao; Tuhina Banerjee; Jane Philip; David Rueda; Andrew L Feig
Journal: Biophys J Date: 2012-03-06 Impact factor: 4.033

Review 3. Epigenetic alterations in aging.

Authors: Susana Gonzalo
Journal: J Appl Physiol (1985) Date: 2010-05-06

4. shRNA expression constructs designed directly from siRNA oligonucleotide sequences.

Authors: Tuva Barøy; Kirsten Sørensen; Mona Mari Lindeberg; Eirik Frengen
Journal: Mol Biotechnol Date: 2010-06 Impact factor: 2.695

5. RNA interference of STAT6 rapidly attenuates ongoing interleukin-13-mediated events in lung epithelial cells.

Authors: William Walker; Gareth D Healey; Julian M Hopkin
Journal: Immunology Date: 2008-10-29 Impact factor: 7.397

6. Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.

Authors: I Dey; M A Giembycz; K Chadee
Journal: Br J Pharmacol Date: 2009-01-23 Impact factor: 8.739

Revealing the world of RNA interference.

1. SHAPE-directed discovery of potent shRNA inhibitors of HIV-1.

2. Thermodynamic and kinetic analysis of an RNA kissing interaction and its resolution into an extended duplex.

Review 3. Epigenetic alterations in aging.

4. shRNA expression constructs designed directly from siRNA oligonucleotide sequences.

5. RNA interference of STAT6 rapidly attenuates ongoing interleukin-13-mediated events in lung epithelial cells.

6. Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines.

Review 7. Origins and Mechanisms of miRNAs and siRNAs.

8. The expression level of the voltage-dependent anion channel controls life and death of the cell.

Review 9. siRNA-based therapeutic approaches for rheumatic diseases.

Review 10. The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.