Sahana N Kukke1, Ana Carolina de Campos2, Diane Damiano2, Katharine E Alter3, Nicholas Patronas4, Mark Hallett5. 1. Biomedical Engineering Department, The Catholic University of America, USA; Rehabilitation Medicine Department, National Institutes of Health Clinical Center, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA. 2. Rehabilitation Medicine Department, National Institutes of Health Clinical Center, USA. 3. Rehabilitation Medicine Department, National Institutes of Health Clinical Center, USA; Mount Washington Pediatric Hospital, USA. 4. Radiology Department, National Institutes of Health Clinical Center, USA. 5. National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA. Electronic address: hallettm@ninds.nih.gov.
Abstract
OBJECTIVE: Dystonia is a disabling motor disorder often without effective therapies. To better understand the genesis of dystonia after childhood stroke, we analyzed electroencephalographic (EEG) recordings in this population. METHODS: Resting spectral power of EEG signals over bilateral sensorimotor cortices (Powrest), resting inter-hemispheric sensorimotor coherence (Cohrest), and task-related changes in power (TRPow) and coherence (TRCoh) during wrist extension were analyzed in individuals with dystonia (age 20±3years) and healthy volunteers (age 17±5years). RESULTS: Ipsilesional TRPow decrease was significantly lower in patients than controls during the more affected wrist task. Force deficits of the affected wrist correlated with reduced alpha TRPow decrease on the ipsilesional and not the contralesional hemisphere. Cohrest was significantly lower in patients than controls, and correlated with more severe dystonia and poorer hand function. Powrest and TRCoh were similar between groups. CONCLUSIONS: The association between weakness and cortical activation during wrist extension highlights the importance of ipsilesional sensorimotor activation on function. Reduction of Cohrest in patients reflects a loss of inter-hemispheric connectivity that may result from structural changes and neuroplasticity, potentially contributing to the development of dystonia. SIGNIFICANCE: Cortical and motor dysfunction are correlated in patients with childhood stroke and may in part explain the genesis of dystonia. Published by Elsevier Ireland Ltd.
OBJECTIVE:Dystonia is a disabling motor disorder often without effective therapies. To better understand the genesis of dystonia after childhood stroke, we analyzed electroencephalographic (EEG) recordings in this population. METHODS: Resting spectral power of EEG signals over bilateral sensorimotor cortices (Powrest), resting inter-hemispheric sensorimotor coherence (Cohrest), and task-related changes in power (TRPow) and coherence (TRCoh) during wrist extension were analyzed in individuals with dystonia (age 20±3years) and healthy volunteers (age 17±5years). RESULTS: Ipsilesional TRPow decrease was significantly lower in patients than controls during the more affected wrist task. Force deficits of the affected wrist correlated with reduced alpha TRPow decrease on the ipsilesional and not the contralesional hemisphere. Cohrest was significantly lower in patients than controls, and correlated with more severe dystonia and poorer hand function. Powrest and TRCoh were similar between groups. CONCLUSIONS: The association between weakness and cortical activation during wrist extension highlights the importance of ipsilesional sensorimotor activation on function. Reduction of Cohrest in patients reflects a loss of inter-hemispheric connectivity that may result from structural changes and neuroplasticity, potentially contributing to the development of dystonia. SIGNIFICANCE: Cortical and motor dysfunction are correlated in patients with childhood stroke and may in part explain the genesis of dystonia. Published by Elsevier Ireland Ltd.
Authors: Sahana N Kukke; Lindsey A Curatalo; Ana Carolina de Campos; Mark Hallett; Katharine E Alter; Diane L Damiano Journal: IEEE Trans Neural Syst Rehabil Eng Date: 2015-07-20 Impact factor: 3.802
Authors: Sahana N Kukke; Carmen C Brewer; Christopher Zalewski; Kelly A King; Diane Damiano; Katharine E Alter; Mark Hallett Journal: J Clin Neurophysiol Date: 2017-07 Impact factor: 2.177
Authors: Deniz Doruk; Marcel Simis; Marta Imamura; André R Brunoni; Leon Morales-Quezada; Renato Anghinah; Felipe Fregni; Linamara R Battistella Journal: Front Hum Neurosci Date: 2016-08-30 Impact factor: 3.169