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Literature DB >> 3541896

Glucose-induced accumulation of inositol trisphosphates in isolated pancreatic islets. Predominance of the 1,3,4-isomer.

Abstract

Anion-exchange h.p.l.c. analysis of [3H]inositol phosphates derived from glucose-stimulated isolated pancreatic islets that had been prelabelled with myo-[3H]inositol revealed that the predominant inositol trisphosphate was the 1,3,4-isomer [Ins(1,3,4)P3]. The 1,4,5-isomer [Ins(1,4,5)P3] was also detectable, as was a more polar inositol phosphate with the chromatographic properties of inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. Glucose-induced accumulation of Ins(1,3,4)P3 was augmented by Li+ and occurred after maximal accumulation of Ins(1,4,5)P3. These findings suggest a possible role for Ins(1,3,4)P3 or its probable precursor Ins(1,3,4,5)P4 in stimulus-secretion coupling in pancreatic islets.

Entities: Chemical Disease

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Year: 1986 PMID： 3541896 PMCID： PMC1146973 DOI： 10.1042/bj2370259

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

Authors: B A Wolf; J Turk; W R Sherman; M L McDaniel
Journal: J Biol Chem Date: 1986-03-15 Impact factor: 5.157

2. Inositol phosphates. Profusion and confusion.

Authors: B Michell
Journal: Nature Date: 1986 Jan 16-22 Impact factor: 49.962

Review 3. Regulation of insulin release by calcium.

Authors: C B Wollheim; G W Sharp
Journal: Physiol Rev Date: 1981-10 Impact factor: 37.312

4. Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.

Authors: P Rorsman; H Abrahamsson; E Gylfe; B Hellman
Journal: FEBS Lett Date: 1984-05-07 Impact factor: 4.124

5. A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils.

Authors: A Spät; P G Bradford; J S McKinney; R P Rubin; J W Putney
Journal: Nature Date: 1986 Feb 6-12 Impact factor: 49.962

6. Arachidonic acid metabolism in isolated pancreatic islets. II. The effects of glucose and of inhibitors of arachidonate metabolism on insulin secretion and metabolite synthesis.

Authors: J Turk; J R Colca; N Kotagal; M L McDaniel
Journal: Biochim Biophys Acta Date: 1984-06-06

7. Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products.

Authors: J Turk; J R Colca; N Kotagal; M L McDaniel
Journal: Biochim Biophys Acta Date: 1984-06-06

8. Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

Authors: M Prentki; T J Biden; D Janjic; R F Irvine; M J Berridge; C B Wollheim
Journal: Nature Date: 1984 Jun 7-13 Impact factor: 49.962

9. Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets.

Authors: L Best; W J Malaisse
Journal: Endocrinology Date: 1984-11 Impact factor: 4.736

10. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.

Authors: M J Berridge
Journal: Biochem J Date: 1983-06-15 Impact factor: 3.857

20 in total

1. The relationship between glucose-induced K+ATP channel closure and the rise in [Ca2+]i in single mouse pancreatic beta-cells.

Authors: M Valdeolmillos; A Nadal; D Contreras; B Soria
Journal: J Physiol Date: 1992-09 Impact factor: 5.182

2. Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.

Authors: S B Shears; J B Parry; E K Tang; R F Irvine; R H Michell; C J Kirk
Journal: Biochem J Date: 1987-08-15 Impact factor: 3.857

3. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.

Authors: David A Jacobson; Christopher R Weber; Shunzhong Bao; John Turk; Louis H Philipson
Journal: J Biol Chem Date: 2006-12-29 Impact factor: 5.157

4. Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate.

Authors: S B Shears; D J Storey; A J Morris; A B Cubitt; J B Parry; R H Michell; C J Kirk
Journal: Biochem J Date: 1987-03-01 Impact factor: 3.857

5. Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism.

Authors: R C Inhorn; V S Bansal; P W Majerus
Journal: Proc Natl Acad Sci U S A Date: 1987-04 Impact factor: 11.205

6. Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine. Kinetic analysis of inositol polyphosphate metabolism.

Authors: T J Biden; M L Prugue; A G Davison
Journal: Biochem J Date: 1992-07-15 Impact factor: 3.857

7. Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.

Authors: Michael J MacDonald; Lacmbouh Ade; James M Ntambi; Israr-Ul H Ansari; Scott W Stoker
Journal: J Biol Chem Date: 2015-03-11 Impact factor: 5.157