Literature DB >> 25488670

mTOR trains heightened macrophage responses.

Tiffany Horng1.   

Abstract

The ability of a primary challenge to protect against secondary infection (e.g., during vaccination) independent of the adaptive immune system is mediated in part by macrophage 'training'. Two new studies show that macrophage training is associated with genome-wide epigenetic changes and is regulated by the mTOR pathway and metabolic reprogramming.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 25488670      PMCID： PMC4280324          DOI： 10.1016/j.it.2014.11.004

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  10 in total

Review 1.  Trained immunity: a memory for innate host defense.

Authors:  Mihai G Netea; Jessica Quintin; Jos W M van der Meer
Journal:  Cell Host Microbe       Date:  2011-05-19       Impact factor: 21.023

2.  TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.

Authors:  Bart Everts; Eyal Amiel; Stanley Ching-Cheng Huang; Amber M Smith; Chih-Hao Chang; Wing Y Lam; Veronika Redmann; Tori C Freitas; Julianna Blagih; Gerritje J W van der Windt; Maxim N Artyomov; Russell G Jones; Erika L Pearce; Edward J Pearce
Journal:  Nat Immunol       Date:  2014-02-23       Impact factor: 25.606

Review 3.  Histone methyl transferases and demethylases; can they link metabolism and transcription?

Authors:  Raffaele Teperino; Kristina Schoonjans; Johan Auwerx
Journal:  Cell Metab       Date:  2010-10-06       Impact factor: 27.287

Review 4.  Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response.

Authors:  Katherine Y King; Margaret A Goodell
Journal:  Nat Rev Immunol       Date:  2011-09-09       Impact factor: 53.106

Review 5.  Metabolism of inflammation limited by AMPK and pseudo-starvation.

Authors:  Luke A J O'Neill; D Grahame Hardie
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962

Review 6.  Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

Authors:  Christian C Dibble; Brendan D Manning
Journal:  Nat Cell Biol       Date:  2013-06       Impact factor: 28.824

7.  mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Authors:  Shih-Chin Cheng; Jessica Quintin; Robert A Cramer; Kelly M Shepardson; Sadia Saeed; Vinod Kumar; Evangelos J Giamarellos-Bourboulis; Joost H A Martens; Nagesha Appukudige Rao; Ali Aghajanirefah; Ganesh R Manjeri; Yang Li; Daniela C Ifrim; Rob J W Arts; Brian M J W van der Veer; Brian M J W van der Meer; Peter M T Deen; Colin Logie; Luke A O'Neill; Peter Willems; Frank L van de Veerdonk; Jos W M van der Meer; Aylwin Ng; Leo A B Joosten; Cisca Wijmenga; Hendrik G Stunnenberg; Ramnik J Xavier; Mihai G Netea
Journal:  Science       Date:  2014-09-26       Impact factor: 47.728

8.  Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

Authors:  Sadia Saeed; Jessica Quintin; Hindrik H D Kerstens; Nagesha A Rao; Ali Aghajanirefah; Filomena Matarese; Shih-Chin Cheng; Jacqueline Ratter; Kim Berentsen; Martijn A van der Ent; Nilofar Sharifi; Eva M Janssen-Megens; Menno Ter Huurne; Amit Mandoli; Tom van Schaik; Aylwin Ng; Frances Burden; Kate Downes; Mattia Frontini; Vinod Kumar; Evangelos J Giamarellos-Bourboulis; Willem H Ouwehand; Jos W M van der Meer; Leo A B Joosten; Cisca Wijmenga; Joost H A Martens; Ramnik J Xavier; Colin Logie; Mihai G Netea; Hendrik G Stunnenberg
Journal:  Science       Date:  2014-09-26       Impact factor: 47.728

Review 9.  Tissue-resident macrophages.

Authors:  Luke C Davies; Stephen J Jenkins; Judith E Allen; Philip R Taylor
Journal:  Nat Immunol       Date:  2013-09-18       Impact factor: 25.606

10.  Macrophage activation and polarization: nomenclature and experimental guidelines.

Authors:  Peter J Murray; Judith E Allen; Subhra K Biswas; Edward A Fisher; Derek W Gilroy; Sergij Goerdt; Siamon Gordon; John A Hamilton; Lionel B Ivashkiv; Toby Lawrence; Massimo Locati; Alberto Mantovani; Fernando O Martinez; Jean-Louis Mege; David M Mosser; Gioacchino Natoli; Jeroen P Saeij; Joachim L Schultze; Kari Ann Shirey; Antonio Sica; Jill Suttles; Irina Udalova; Jo A van Ginderachter; Stefanie N Vogel; Thomas A Wynn
Journal:  Immunity       Date:  2014-07-17       Impact factor: 31.745
  10 in total
  4 in total

1.  Altered mTORC1 signalling may contribute to macrophage dysregulation in hidradenitis suppurativa.

Authors:  Valerio De Vita
Journal:  Inflamm Res       Date:  2017-11-11       Impact factor: 4.575

2.  Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities.

Authors:  Sonia Y Velásquez; Doreen Killian; Jutta Schulte; Carsten Sticht; Manfred Thiel; Holger A Lindner
Journal:  J Biol Chem       Date:  2016-04-28       Impact factor: 5.157

Review 3.  Control of macrophage metabolism and activation by mTOR and Akt signaling.

Authors:  Anthony J Covarrubias; H Ibrahim Aksoylar; Tiffany Horng
Journal:  Semin Immunol       Date:  2015-09-07       Impact factor: 11.130

4.  STAT3 governs the HIF-1α response in IL-15 primed human NK cells.

Authors:  Anna Coulibaly; Sonia Y Velásquez; Nina Kassner; Jutta Schulte; Maria Vittoria Barbarossa; Holger A Lindner
Journal:  Sci Rep       Date:  2021-03-29       Impact factor: 4.379
  4 in total

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