| Literature DB >> 25035950 |
Peter J Murray1, Judith E Allen2, Subhra K Biswas3, Edward A Fisher4, Derek W Gilroy5, Sergij Goerdt6, Siamon Gordon7, John A Hamilton8, Lionel B Ivashkiv9, Toby Lawrence10, Massimo Locati11, Alberto Mantovani11, Fernando O Martinez12, Jean-Louis Mege13, David M Mosser14, Gioacchino Natoli15, Jeroen P Saeij16, Joachim L Schultze17, Kari Ann Shirey18, Antonio Sica19, Jill Suttles20, Irina Udalova21, Jo A van Ginderachter22, Stefanie N Vogel18, Thomas A Wynn23.
Abstract
Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation-with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature.Entities:
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Year: 2014 PMID： 25035950 PMCID： PMC4123412 DOI： 10.1016/j.immuni.2014.06.008
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745