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Literature DB >> 2548829

Quantal charge redistributions accompanying the structural transitions of sodium channels.

Abstract

Asymmetric displacement currents, Ig, associated with the gating of nerve sodium channels have been recorded in cell-attached macropatches of Xenopus laevis oocytes injected with exogenous mRNA coding for rat-brain-II sodium channels. The Ig properties were found to be similar to those of gating currents previously observed in native nerve preparations. Ig fluctuations were measured in order to ascertain the discreteness of the conformational changes which precede the channel opening. The auto-correlation of the fluctuations is consistent with a shot-like character of the elementary Ig contributions. The variance of the fluctuations indicates that most of the gating-charge movement that accompanies the activation of a single sodium channel occurs in 2 to 3 brief packets, each carrying an equivalent of about 2.3 electron charges.

Entities: Species

Mesh：

Substances：
Sodium Channels

Year: 1989 PMID： 2548829 DOI： 10.1007/BF00257102

Source DB: PubMed Journal: Eur Biophys J ISSN： 0175-7571 Impact factor: 1.733

29 in total

1. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.

Authors: C Methfessel; V Witzemann; T Takahashi; M Mishina; S Numa; B Sakmann
Journal: Pflugers Arch Date: 1986-12 Impact factor: 3.657

6. The early phase of sodium channel gating current in the squid giant axon. Characteristics of a fast component of displacement charge movement.

Authors: I C Forster; N G Greeff
Journal: Eur Biophys J Date: 1992 Impact factor: 1.733

Quantal charge redistributions accompanying the structural transitions of sodium channels.

1. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels.

2. Structural parts involved in activation and inactivation of the sodium channel.

3. Membrane noise produced by acetylcholine.

Review 4. Conductance fluctuations and ionic pores in membranes.

5. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Review 6. Sodium channel gating: models, mimics, and modifiers.

7. Sodium channels in nerve apparently have two conductance states.

8. Patch clamp characterization of sodium channels expressed from rat brain cDNA.

9. Sodium channel activation in the squid giant axon. Steady state properties.

10. Statistical properties of single sodium channels.

1. Variable ratio of permeability to gating charge of rBIIA sodium channels and sodium influx in Xenopus oocytes.

2. A genetically targetable fluorescent probe of channel gating with rapid kinetics.

3. The screw-helical voltage gating of ion channels.

4. A physical model of potassium channel activation: from energy landscape to gating kinetics.

5. Lighting up single ion channels.

6. The early phase of sodium channel gating current in the squid giant axon. Characteristics of a fast component of displacement charge movement.

7. Noise and stochastic resonance in voltage-gated ion channels.

8. Giga-seal formation alters properties of sodium channels of human myoballs.

9. Gating kinetics of batrachotoxin-modified Na+ channels in the squid giant axon. Voltage and temperature effects.

10. A membrane-based force generation mechanism in auditory sensory cells.