Literature DB >> 2543931

Structural parts involved in activation and inactivation of the sodium channel.

W Stühmer1, F Conti, H Suzuki, X D Wang, M Noda, N Yahagi, H Kubo, S Numa.   

Abstract

Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

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Year:  1989        PMID： 2543931     DOI： 10.1038/339597a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  383 in total

1.  A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons.

Authors:  N Gilles; C Blanchet; I Shichor; M Zaninetti; I Lotan; D Bertrand; D Gordon
Journal:  J Neurosci       Date:  1999-10-15       Impact factor: 6.167

2.  Effects of channel cytoplasmic regions on the activation mechanisms of cardiac versus skeletal muscle Na(+) channels.

Authors:  E S Bennett
Journal:  Biophys J       Date:  1999-12       Impact factor: 4.033

3.  The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G.

Authors:  M Staes; K Talavera; N Klugbauer; J Prenen; L Lacinova; G Droogmans; F Hofmann; B Nilius
Journal:  J Physiol       Date:  2001-01-01       Impact factor: 5.182

4.  Control of gating mode by a single amino acid residue in transmembrane segment IS3 of the N-type Ca2+ channel.

Authors:  H Zhong; B Li; T Scheuer; W A Catterall
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

5.  Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells.

Authors:  R K Ellerkmann; V Riazanski; C E Elger; B W Urban; H Beck
Journal:  J Physiol       Date:  2001-04-15       Impact factor: 5.182

6.  A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state.

Authors:  J P O'Reilly; S Y Wang; G K Wang
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

7.  Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

Authors:  R Planells-Cases; M Caprini; J Zhang; E M Rockenstein; R R Rivera; C Murre; E Masliah; M Montal
Journal:  Biophys J       Date:  2000-06       Impact factor: 4.033

8.  Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes.

Authors:  Z Zhou; D M Bers
Journal:  J Physiol       Date:  2000-02-15       Impact factor: 5.182

9.  On mutations that uncouple sodium channel activation from inactivation.

Authors:  L Goldman
Journal:  Biophys J       Date:  1999-05       Impact factor: 4.033

10.  N-type calcium channel inactivation probed by gating-current analysis.

Authors:  L P Jones; C D DeMaria; D T Yue
Journal:  Biophys J       Date:  1999-05       Impact factor: 4.033
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