Fast and adaptive detection of pulmonary nodules in thoracic CT images using a hierarchical vector quantization scheme.

Computer-aided detection (CADe) of pulmonary nodules is critical to assisting radiologists in early identification of lung cancer from computed tomography (CT) scans. This paper proposes a novel CADe system based on a hierarchical vector quantization (VQ) scheme. Compared with the commonly-used simple thresholding approach, the high-level VQ yields a more accurate segmentation of the lungs from the chest volume. In identifying initial nodule candidates (INCs) within the lungs, the low-level VQ proves to be effective for INCs detection and segmentation, as well as computationally efficient compared to existing approaches. False-positive (FP) reduction is conducted via rule-based filtering operations in combination with a feature-based support vector machine classifier. The proposed system was validated on 205 patient cases from the publically available online Lung Image Database Consortium database, with each case having at least one juxta-pleural nodule annotation. Experimental results demonstrated that our CADe system obtained an overall sensitivity of 82.7% at a specificity of 4 FPs/scan. Especially for the performance on juxta-pleural nodules, we observed 89.2% sensitivity at 4.14 FPs/scan. With respect to comparable CADe systems, the proposed system shows outperformance and demonstrates its potential for fast and adaptive detection of pulmonary nodules via CT imaging.