Tye E Arbuckle1, Lorelle Weiss2, Mandy Fisher3, Russ Hauser4, Pierre Dumas5, René Bérubé5, Angelica Neisa3, Alain LeBlanc5, Carly Lang3, Pierre Ayotte6, Mark Walker7, Mark Feeley8, Diane Koniecki9, George Tawagi10. 1. Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa ON, Canada. Electronic address: Tye.Arbuckle@hc-sc.gc.ca. 2. Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa ON, Canada. 3. Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa ON, Canada. 4. Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States. 5. Centre de Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec, QC, Canada. 6. Centre de Toxicologie du Québec (CTQ), Institut National de Santé Publique du Québec (INSPQ), Québec, QC, Canada; Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU Québec, Québec, QC, Canada. 7. Department of Obstetrics and Gynecology, University of Ottawa, Ottawa ON, Canada. 8. Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada. 9. Consumer Product Safety Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada. 10. Department of Obstetrics and Perinatal Medicine, Ottawa Hospital, Ottawa, ON, Canada.
Abstract
BACKGROUND: Results of recent national surveys have shown the high prevalence of exposure to bisphenol A (BPA) and triclosan (TCS) among the general population; however biomonitoring data for pregnant women and infants are limited. METHODS: Women (n=80) were recruited from early prenatal clinics and asked to collect urine samples multiple times during pregnancy and once 2-3 months post-partum. Samples of infant urine and meconium as well as breast milk and infant formula were also collected. Biospecimens were analyzed by GC-MS/MS for BPA, TCS and triclocarban (TCC). RESULTS: Triclosan was detected in over 80% of the maternal urines (geometric mean (GM): 21.61 μg/L), 60% of the infant urines (GM: 2.8 μg/L), 46% of the breast milk and 80% of the meconium samples. Triclocarban was rarely detected in any of the biospecimens. Median total BPA concentrations were 1.21 and 0.24 μg/L in maternal and infant urines, respectively. Free BPA was detected in only 11% of infant urine samples. The meconium of female infants had significantly higher concentrations of total BPA and TCS than those of males, while no differences were observed in infant urine concentrations by sex. CONCLUSIONS: We found widespread exposure among pregnant women and infants to environmental phenols, with large inter-individual variability in exposure to triclosan. These data will contribute to the risk assessment of these chemicals, especially in susceptible sub-populations. Crown
BACKGROUND: Results of recent national surveys have shown the high prevalence of exposure to bisphenol A (BPA) and triclosan (TCS) among the general population; however biomonitoring data for pregnant women and infants are limited. METHODS:Women (n=80) were recruited from early prenatal clinics and asked to collect urine samples multiple times during pregnancy and once 2-3 months post-partum. Samples of infant urine and meconium as well as breast milk and infant formula were also collected. Biospecimens were analyzed by GC-MS/MS for BPA, TCS and triclocarban (TCC). RESULTS:Triclosan was detected in over 80% of the maternal urines (geometric mean (GM): 21.61 μg/L), 60% of the infant urines (GM: 2.8 μg/L), 46% of the breast milk and 80% of the meconium samples. Triclocarban was rarely detected in any of the biospecimens. Median total BPA concentrations were 1.21 and 0.24 μg/L in maternal and infant urines, respectively. Free BPA was detected in only 11% of infant urine samples. The meconium of female infants had significantly higher concentrations of total BPA and TCS than those of males, while no differences were observed in infant urine concentrations by sex. CONCLUSIONS: We found widespread exposure among pregnant women and infants to environmental phenols, with large inter-individual variability in exposure to triclosan. These data will contribute to the risk assessment of these chemicals, especially in susceptible sub-populations. Crown
Authors: Taylor Etzel; Gina Muckle; Tye E Arbuckle; William D Fraser; Emmanuel Ouellet; Jean R Séguin; Bruce Lanphear; Joseph M Braun Journal: Environ Int Date: 2018-03-02 Impact factor: 9.621
Authors: Shaina L Stacy; Melissa Eliot; Taylor Etzel; George Papandonatos; Antonia M Calafat; Aimin Chen; Russ Hauser; Bruce P Lanphear; Sheela Sathyanarayana; Xiaoyun Ye; Kimberly Yolton; Joseph M Braun Journal: Environ Sci Technol Date: 2017-05-25 Impact factor: 9.028