Medina S Jackson-Browne1, Noelle Henderson2, Marisa Patti2, Adam Spanier3, Joseph M Braun2. 1. Epidemiology Program, College of Health Sciences, University of Delaware, 100 Discovery Blvd, 7th floor, Newark, DE, USA. mjbrowne@udel.edu. 2. Department of Epidemiology, Brown University, Providence, RI, USA. 3. Department of Pediatrics, Division of General Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Abstract
PURPOSE OF REVIEW: We examined recent research on associations of prenatal and early-childhood exposure to the antimicrobial compounds, triclosan, and parabens, with the risk of asthma and eczema in children. We will discuss potential biological mechanisms of this association and highlight strengths and limitations of the study design and exposure assessment of current findings. RECENT FINDINGS: Results of available toxicological and epidemiologic studies indicate a potential link of triclosan and paraben exposures with asthma and eczema in children, as well as changes in microbiome diversity and immune dysfunction, which could possibly mediate an association with the health outcomes. A small number of studies suggest that triclosan and paraben exposures could be related to the risk of asthma and eczema in children. Although current findings are far from conclusive, there is emerging evidence that changes in microbiome diversity and immune function from antimicrobial exposure may mediate these relations.
PURPOSE OF REVIEW: We examined recent research on associations of prenatal and early-childhood exposure to the antimicrobial compounds, triclosan, and parabens, with the risk of asthma and eczema in children. We will discuss potential biological mechanisms of this association and highlight strengths and limitations of the study design and exposure assessment of current findings. RECENT FINDINGS: Results of available toxicological and epidemiologic studies indicate a potential link of triclosan and paraben exposures with asthma and eczema in children, as well as changes in microbiome diversity and immune dysfunction, which could possibly mediate an association with the health outcomes. A small number of studies suggest that triclosan and paraben exposures could be related to the risk of asthma and eczema in children. Although current findings are far from conclusive, there is emerging evidence that changes in microbiome diversity and immune function from antimicrobial exposure may mediate these relations.
Authors: C Braun-Fahrländer; M Gassner; L Grize; U Neu; F H Sennhauser; H S Varonier; J C Vuille; B Wüthrich Journal: Clin Exp Allergy Date: 1999-01 Impact factor: 5.018
Authors: Randi J Bertelsen; Stephanie M Engel; Todd A Jusko; Antonia M Calafat; Jane A Hoppin; Stephanie J London; Merete Eggesbø; Heidi Aase; Pål Zeiner; Ted Reichborn-Kjennerud; Gun P Knudsen; Virginia T Guidry; Matthew P Longnecker Journal: J Expo Sci Environ Epidemiol Date: 2014-01-29 Impact factor: 5.563
Authors: Max T Aung; Kelly K Ferguson; David E Cantonwine; Kelly M Bakulski; Bhramar Mukherjee; Rita Loch-Caruso; Thomas F McElrath; John D Meeker Journal: Sci Total Environ Date: 2018-08-29 Impact factor: 7.963
Authors: Rachel Baur; Jasleen Gandhi; Nikki B Marshall; Ewa Lukomska; Lisa M Weatherly; Hillary L Shane; Gangqing Hu; Stacey E Anderson Journal: Toxicol Sci Date: 2021-11-24 Impact factor: 4.849
Authors: Slawomir Gonkowski; Manolis Tzatzarakis; Elena Vakonaki; Krystyna Makowska; Aristidis M Tsatsakis; Joanna Wojtkiewicz Journal: Int J Environ Res Public Health Date: 2022-03-23 Impact factor: 3.390