Literature DB >> 25475057

FTO: linking m6A demethylation to adipogenesis.

Moshe Shay Ben-Haim1, Sharon Moshitch-Moshkovitz2, Gideon Rechavi1.   

Abstract

Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

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Year:  2014        PMID： 25475057      PMCID： PMC4650590          DOI： 10.1038/cr.2014.162

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

Review 1.  Gene expression regulation mediated through reversible m⁶A RNA methylation.

Authors:  Ye Fu; Dan Dominissini; Gideon Rechavi; Chuan He
Journal:  Nat Rev Genet       Date:  2014-03-25       Impact factor: 53.242

2.  Inactivation of the Fto gene protects from obesity.

Authors:  Julia Fischer; Linda Koch; Christian Emmerling; Jeanette Vierkotten; Thomas Peters; Jens C Brüning; Ulrich Rüther
Journal:  Nature       Date:  2009-02-22       Impact factor: 49.962

3.  A link between FTO, ghrelin, and impaired brain food-cue responsivity.

Authors:  Efthimia Karra; Owen G O'Daly; Agharul I Choudhury; Ahmed Yousseif; Steven Millership; Marianne T Neary; William R Scott; Keval Chandarana; Sean Manning; Martin E Hess; Hiroshi Iwakura; Takashi Akamizu; Queensta Millet; Cigdem Gelegen; Megan E Drew; Sofia Rahman; Julian J Emmanuel; Steven C R Williams; Ulrich U Rüther; Jens C Brüning; Dominic J Withers; Fernando O Zelaya; Rachel L Batterham
Journal:  J Clin Invest       Date:  2013-07-15       Impact factor: 14.808

4.  The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

Authors:  Martin E Hess; Simon Hess; Kate D Meyer; Linda A W Verhagen; Linda Koch; Hella S Brönneke; Marcelo O Dietrich; Sabine D Jordan; Yogesh Saletore; Olivier Elemento; Bengt F Belgardt; Thomas Franz; Tamas L Horvath; Ulrich Rüther; Samie R Jaffrey; Peter Kloppenburg; Jens C Brüning
Journal:  Nat Neurosci       Date:  2013-06-30       Impact factor: 24.884

5.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors:  Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

6.  Overexpression of Fto leads to increased food intake and results in obesity.

Authors:  Chris Church; Lee Moir; Fiona McMurray; Christophe Girard; Gareth T Banks; Lydia Teboul; Sara Wells; Jens C Brüning; Patrick M Nolan; Frances M Ashcroft; Roger D Cox
Journal:  Nat Genet       Date:  2010-11-14       Impact factor: 38.330

7.  N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Authors:  Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Journal:  Nat Chem Biol       Date:  2011-10-16       Impact factor: 15.040

8.  Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.

Authors:  Xiao-Li Ping; Bao-Fa Sun; Lu Wang; Wen Xiao; Xin Yang; Wen-Jia Wang; Samir Adhikari; Yue Shi; Ying Lv; Yu-Sheng Chen; Xu Zhao; Ang Li; Ying Yang; Ujwal Dahal; Xiao-Min Lou; Xi Liu; Jun Huang; Wei-Ping Yuan; Xiao-Fan Zhu; Tao Cheng; Yong-Liang Zhao; Xinquan Wang; Jannie M Rendtlew Danielsen; Feng Liu; Yun-Gui Yang
Journal:  Cell Res       Date:  2014-01-10       Impact factor: 25.617

9.  FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

Authors:  Xu Zhao; Ying Yang; Bao-Fa Sun; Yue Shi; Xin Yang; Wen Xiao; Ya-Juan Hao; Xiao-Li Ping; Yu-Sheng Chen; Wen-Jia Wang; Kang-Xuan Jin; Xing Wang; Chun-Min Huang; Yu Fu; Xiao-Meng Ge; Shu-Hui Song; Hyun Seok Jeong; Hiroyuki Yanagisawa; Yamei Niu; Gui-Fang Jia; Wei Wu; Wei-Min Tong; Akimitsu Okamoto; Chuan He; Jannie M Rendtlew Danielsen; Xiu-Jie Wang; Yun-Gui Yang
Journal:  Cell Res       Date:  2014-11-21       Impact factor: 25.617

10.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors:  Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal:  Nature       Date:  2012-04-29       Impact factor: 49.962
  10 in total
  39 in total

Review 1.  N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction.

Authors:  Jiaxin Chen; Xiao Fang; Pengcheng Zhong; Zhangfa Song; Xiaotong Hu
Journal:  RNA Biol       Date:  2019-05-26       Impact factor: 4.652

2.  FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.

Authors:  Zejuan Li; Hengyou Weng; Rui Su; Xiaocheng Weng; Zhixiang Zuo; Chenying Li; Huilin Huang; Sigrid Nachtergaele; Lei Dong; Chao Hu; Xi Qin; Lichun Tang; Yungui Wang; Gia-Ming Hong; Hao Huang; Xiao Wang; Ping Chen; Sandeep Gurbuxani; Stephen Arnovitz; Yuanyuan Li; Shenglai Li; Jennifer Strong; Mary Beth Neilly; Richard A Larson; Xi Jiang; Pumin Zhang; Jie Jin; Chuan He; Jianjun Chen
Journal:  Cancer Cell       Date:  2016-12-22       Impact factor: 31.743

3.  The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells.

Authors:  Dongling Zou; Lei Dong; Chenying Li; Zhe Yin; Shuan Rao; Qi Zhou
Journal:  Cancer Cell Int       Date:  2019-12-02       Impact factor: 5.722

4.  Modeling multi-species RNA modification through multi-task curriculum learning.

Authors:  Yuanpeng Xiong; Xuan He; Dan Zhao; Tingzhong Tian; Lixiang Hong; Tao Jiang; Jianyang Zeng
Journal:  Nucleic Acids Res       Date:  2021-04-19       Impact factor: 16.971

5.  Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication.

Authors:  Fengchun Ye; E Ricky Chen; Timothy W Nilsen
Journal:  J Virol       Date:  2017-07-27       Impact factor: 5.103

Review 6.  Deciphering the Epitranscriptomic Signatures in Cell Fate Determination and Development.

Authors:  Varun Haran; Nibedita Lenka
Journal:  Stem Cell Rev Rep       Date:  2019-08       Impact factor: 5.739

Review 7.  Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications.

Authors:  Curtis A Nutter; Muge N Kuyumcu-Martinez
Journal:  Wiley Interdiscip Rev RNA       Date:  2017-12-27       Impact factor: 9.957

Review 8.  Update: Mechanisms Underlying N6-Methyladenosine Modification of Eukaryotic mRNA.

Authors:  Yang Wang; Jing Crystal Zhao
Journal:  Trends Genet       Date:  2016-10-25       Impact factor: 11.639

9.  MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein.

Authors:  Zhe Yang; Jiong Li; Guoxing Feng; Shan Gao; Yuan Wang; Shuqin Zhang; Yunxia Liu; Lihong Ye; Yueguo Li; Xiaodong Zhang
Journal:  J Biol Chem       Date:  2017-01-19       Impact factor: 5.157

10.  N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications.

Authors:  Yang Wang; Yue Li; Minghui Yue; Jun Wang; Sandeep Kumar; Robert J Wechsler-Reya; Zhaolei Zhang; Yuya Ogawa; Manolis Kellis; Gregg Duester; Jing Crystal Zhao
Journal:  Nat Neurosci       Date:  2018-01-15       Impact factor: 24.884
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