Literature DB >> 25473169

Mitochondrial DNA alterations in the progression of gastric carcinomas: unexplored issues and future research needs.

Luciana Rigoli1, Rosario Alberto Caruso1.   

Abstract

Gastric cancer is the second most frequent cause of cancer death worldwide. Patients infected with Helicobacter pylori (H. pylori) are at increased risk of gastric cancer. H. pylori induces genomic instability in both nuclear and mitochondrial (mt) DNA of gastric epithelial cells. Changes in mtDNA represent an early event during gastric tumorigenesis, and thus may serve as potential biomarkers for early detection and prognosis in gastric carcinoma.This review article summarizes the mtDNA mutations that have been reported in gastric carcinomas and their precancerous conditions. Unexplored research topics, such as the role of mtDNA alterations in an alternative pathway of gastric carcinogenesis, are identified and directions for future research are suggested.

Entities:  

Keywords:  Gastric carcinoma; Histopathology; Molecular biology; Precancerous lesions; mtDNA

Mesh：

Substances：

Year:  2014        PMID： 25473169      PMCID： PMC4239503          DOI： 10.3748/wjg.v20.i43.16159

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  74 in total

1.  Dysplasia of nonmetaplastic gastric mucosa. A proposal for its classification and its possible relationship to diffuse-type gastric carcinoma.

Authors:  L Ghandur-Mnaymneh; J Paz; E Roldan; J Cassady
Journal:  Am J Surg Pathol       Date:  1988-02       Impact factor: 6.394

2.  Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations.

Authors:  Kimiyasu Yamazaki; Yusuke Tajima; Reiko Makino; Nobukazu Nishino; Shigeo Aoki; Masanori Kato; Masaaki Sakamoto; Koji Morohara; Tsutomu Kaetsu; Mitsuo Kusano
Journal:  World J Gastroenterol       Date:  2006-06-28       Impact factor: 5.742

3.  The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis.

Authors:  Lisette G Capelle; Annemarie C de Vries; Jelle Haringsma; Frank Ter Borg; Richard A de Vries; Marco J Bruno; Herman van Dekken; Jos Meijer; Nicole C T van Grieken; Ernst J Kuipers
Journal:  Gastrointest Endosc       Date:  2010-04-09       Impact factor: 9.427

4.  Sequence and organization of the human mitochondrial genome.

Authors:  S Anderson; A T Bankier; B G Barrell; M H de Bruijn; A R Coulson; J Drouin; I C Eperon; D P Nierlich; B A Roe; F Sanger; P H Schreier; A J Smith; R Staden; I G Young
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

Review 5.  Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice.

Authors:  Parry Guilford; Bostjan Humar; Vanessa Blair
Journal:  Gastric Cancer       Date:  2010-04-07       Impact factor: 7.370

Review 6.  Atrophy-metaplasia-dysplasia-carcinoma sequence in the stomach: a reality or merely an hypothesis?

Authors:  A Meining; A Morgner; S Miehlke; E Bayerdörffer; M Stolte
Journal:  Best Pract Res Clin Gastroenterol       Date:  2001-12       Impact factor: 3.043

7.  Mucin profiles in signet-ring cell carcinoma.

Authors:  Minh D Nguyen; Brian Plasil; Ping Wen; Wendy L Frankel
Journal:  Arch Pathol Lab Med       Date:  2006-06       Impact factor: 5.534

8.  ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Authors:  Kaori Ishikawa; Keizo Takenaga; Miho Akimoto; Nobuko Koshikawa; Aya Yamaguchi; Hirotake Imanishi; Kazuto Nakada; Yoshio Honma; Jun-Ichi Hayashi
Journal:  Science       Date:  2008-04-03       Impact factor: 47.728

9.  Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells.

Authors:  Ana Manuel Dantas Machado; Ceu Figueiredo; Eliette Touati; Valdemar Máximo; Sonia Sousa; Valérie Michel; Fátima Carneiro; Finn Cilius Nielsen; Raquel Seruca; Lene Juel Rasmussen
Journal:  Clin Cancer Res       Date:  2009-04-21       Impact factor: 12.531

10.  Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis.

Authors:  Stephanie A Navarro Silvera; Susan T Mayne; Marilie D Gammon; Thomas L Vaughan; Wong-Ho Chow; Joel A Dubin; Robert Dubrow; Janet L Stanford; A Brian West; Heidrun Rotterdam; William J Blot; Harvey A Risch
Journal:  Ann Epidemiol       Date:  2013-10-18       Impact factor: 6.996
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  3 in total

1.  Identification of An mtDNA Setpoint Associated with Highest Levels of CD44 Positivity and Chemoresistance in HGC-27 and MKN-45 Gastric Cancer Cell Lines.

Authors:  Gökhan Terzioğlu; Özlem Türksoy; Ömer Faruk Bayrak
Journal:  Cell J       Date:  2018-05-15       Impact factor: 2.479

Review 2.  Metabolic reprogramming results in abnormal glycolysis in gastric cancer: a review.

Authors:  Yuanda Liu; Ze Zhang; Junyang Wang; Chao Chen; Xiaohuan Tang; Jiaming Zhu; Jingjing Liu
Journal:  Onco Targets Ther       Date:  2019-02-13       Impact factor: 4.147

Review 3.  HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach.

Authors:  A Ieni; V Barresi; L Rigoli; R A Caruso; G Tuccari
Journal:  Dis Markers       Date:  2015-10-01       Impact factor: 3.434
  3 in total

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