| Literature DB >> 25467443 |
Eunyoung Chae1, Kirsten Bomblies1, Sang-Tae Kim1, Darya Karelina2, Maricris Zaidem1, Stephan Ossowski1, Carmen Martín-Pizarro1, Roosa A E Laitinen1, Beth A Rowan1, Hezi Tenenboim1, Sarah Lechner1, Monika Demar1, Anette Habring-Müller1, Christa Lanz1, Gunnar Rätsch3, Detlef Weigel4.
Abstract
Intraspecific genetic incompatibilities prevent the assembly of specific alleles into single genotypes and influence genome- and species-wide patterns of sequence variation. A common incompatibility in plants is hybrid necrosis, characterized by autoimmune responses due to epistatic interactions between natural genetic variants. By systematically testing thousands of F1 hybrids of Arabidopsis thaliana strains, we identified a small number of incompatibility hot spots in the genome, often in regions densely populated by nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes. In several cases, these immune receptor loci interact with each other, suggestive of conflict within the immune system. A particularly dangerous locus is a highly variable cluster of NLR genes, DM2, which causes multiple independent incompatibilities with genes that encode a range of biochemical functions, including NLRs. Our findings suggest that deleterious interactions of immune receptors limit the combinations of favorable disease resistance alleles accessible to plant genomes.Entities:
Mesh：
Year: 2014 PMID： 25467443 PMCID： PMC4269942 DOI： 10.1016/j.cell.2014.10.049
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582