Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Structure and mechanism of lanthipeptide biosynthetic enzymes.

Literature DB >> 25460269

Structure and mechanism of lanthipeptide biosynthetic enzymes.

Wilfred A van der Donk¹, Satish K Nair².

Abstract

Lanthipeptides are members of the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. They contain thioether crosslinks generated by dehydration of Ser and Thr residues followed by the addition of the thiol of Cys residues to the dehydroamino acids. Recent studies have revealed unexpected mechanisms of the post-translational modifications, and structural studies have started to provide insights into recognition of the peptide substrates by the modification enzymes.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25460269 PMCID： PMC4267917 DOI： 10.1016/j.sbi.2014.09.006

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

69 in total

1. Requirements of the engineered leader peptide of nisin for inducing modification, export, and cleavage.

Authors: Annechien Plat; Leon D Kluskens; Anneke Kuipers; Rick Rink; Gert N Moll
Journal: Appl Environ Microbiol Date: 2010-11-19 Impact factor: 4.792

2. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.

Authors: Chao Huang; Mina Chen; Dejiang Pang; Dandan Bi; Yi Zou; Xiaoqiang Xia; Weiwei Yang; Liping Luo; Rongkang Deng; Honglin Tan; Liang Zhou; Shouyang Yu; Liheng Guo; XiaoXia Du; Yiyuan Cui; Jiahua Hu; Qing Mao; Paul F Worley; Bo Xiao
Journal: Dev Cell Date: 2014-08-25 Impact factor: 12.270

3. Labyrinthopeptins: a new class of carbacyclic lantibiotics.

Authors: Kathrin Meindl; Timo Schmiederer; Kathrin Schneider; Andreas Reicke; Diane Butz; Simone Keller; Hans Gühring; László Vértesy; Joachim Wink; Holger Hoffmann; Mark Brönstrup; George M Sheldrick; Roderich D Süssmuth
Journal: Angew Chem Int Ed Engl Date: 2010-02-01 Impact factor: 15.336

4. In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification.

Authors: Wolfgang M Müller; Timo Schmiederer; Paul Ensle; Roderich D Süssmuth
Journal: Angew Chem Int Ed Engl Date: 2010-03-22 Impact factor: 15.336

5. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS.

Authors: Qi Zhang; Manuel Ortega; Yanxiang Shi; Huan Wang; Joel O Melby; Weixin Tang; Douglas A Mitchell; Wilfred A van der Donk
Journal: Proc Natl Acad Sci U S A Date: 2014-08-04 Impact factor: 11.205

6. Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights.

Authors: Yuki Goto; Bo Li; Jan Claesen; Yanxiang Shi; Mervyn J Bibb; Wilfred A van der Donk
Journal: PLoS Biol Date: 2010-03-23 Impact factor: 8.029

7. Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids.

Authors: Christopher T Lohans; Jessica L Li; John C Vederas
Journal: J Am Chem Soc Date: 2014-09-10 Impact factor: 15.419

8. Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO.

Authors: Manuel A Ortega; Juan E Velásquez; Neha Garg; Qi Zhang; Rachel E Joyce; Satish K Nair; Wilfred A van der Donk
Journal: ACS Chem Biol Date: 2014-06-06 Impact factor: 5.100

Review 9. Emerging biological importance of central nervous system lanthionines.

Authors: Kenneth Hensley; Kalina Venkova; Alexandar Christov
Journal: Molecules Date: 2010-08-13 Impact factor: 4.411

10. Recognition sequences and substrate evolution in cyanobactin biosynthesis.

Authors: Debosmita Sardar; Elizabeth Pierce; John A McIntosh; Eric W Schmidt
Journal: ACS Synth Biol Date: 2014-03-26 Impact factor: 5.110

9 in total

Review 1. Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

Authors: Lindsay M Repka; Jonathan R Chekan; Satish K Nair; Wilfred A van der Donk
Journal: Chem Rev Date: 2017-01-30 Impact factor: 60.622

2. O-Methyltransferase-Mediated Incorporation of a β-Amino Acid in Lanthipeptides.

Authors: Jeella Z Acedo; Ian R Bothwell; Linna An; Abby Trouth; Clara Frazier; Wilfred A van der Donk
Journal: J Am Chem Soc Date: 2019-10-15 Impact factor: 15.419

Review 3. Combinatorial biosynthesis of RiPPs: docking with marine life.

Authors: Debosmita Sardar; Eric W Schmidt
Journal: Curr Opin Chem Biol Date: 2015-12-19 Impact factor: 8.822

4. Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

Authors: Julian D Hegemann; Wilfred A van der Donk
Journal: J Am Chem Soc Date: 2018-04-19 Impact factor: 15.419

5. One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase.

Authors: Jian Wang; Xiaoxuan Ge; Li Zhang; Kunling Teng; Jin Zhong
Journal: Sci Rep Date: 2016-12-07 Impact factor: 4.379

6. Characterization and complete genome analysis of the surfactin-producing, plant-protecting bacterium Bacillus velezensis 9D-6.

Authors: Elliot Nicholas Grady; Jacqueline MacDonald; Margaret T Ho; Brian Weselowski; Tim McDowell; Ori Solomon; Justin Renaud; Ze-Chun Yuan
Journal: BMC Microbiol Date: 2019-01-08 Impact factor: 3.605