Literature DB >> 25456384

Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity.

Marina Roussaki1, Konstantinos Zelianaios2, Eleni Kavetsou2, Stylianos Hamilakis2, Dimitra Hadjipavlou-Litina3, Christos Kontogiorgis3, Thalia Liargkova3, Anastasia Detsi2.   

Abstract

In the present project, a series of coumarin analogues, were synthesised and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity. A variety of structural modifications on the coumarin scaffold revealed interesting structure–activity relationships concerning the different biological assays. Prenyloxy-coumarins 9 and 10 displayed the best combined inhibition of lipid peroxidation and soybean lipoxygenase. Thiocoumarins 11 and 14 were identified as potent lipoxygenase inhibitors whereas hydrazone analogues 15 and 16 were efficient DPPH radical scavengers.

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Year:  2014        PMID： 25456384     DOI： 10.1016/j.bmc.2014.10.008

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Green Synthesis of Thiazolidine-2,4-dione Derivatives and Their Lipoxygenase Inhibition Activity With QSAR and Molecular Docking Studies.

Authors:  Melita Lončarić; Ivica Strelec; Valentina Pavić; Vesna Rastija; Maja Karnaš; Maja Molnar
Journal:  Front Chem       Date:  2022-07-05       Impact factor: 5.545

Review 2.  Recent development of lipoxygenase inhibitors as anti-inflammatory agents.

Authors:  Chaoyu Hu; Shutao Ma
Journal:  Medchemcomm       Date:  2017-11-29       Impact factor: 3.597

3.  Crystal structure of 3-[2-(thio-phen-3-yl)ethyn-yl]-2H-chromen-2-one.

Authors:  Ignez Caracelli; Stella H Maganhi; Hélio A Stefani; Karina Gueogjian; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-07

4.  Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX.

Authors:  Aikaterini Peperidou; Silvia Bua; Murat Bozdag; Dimitra Hadjipavlou-Litina; Claudiu T Supuran
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

Review 5.  Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds.

Authors:  Juliana Helena Castro E Silva; Rafael Short Ferreira; Erica Patricia Pereira; Suzana Braga-de-Souza; Monique Marylin Alves de Almeida; Cleonice Creusa Dos Santos; Arthur Morgan Butt; Elisabetta Caiazzo; Raffaele Capasso; Victor Diogenes Amaral da Silva; Silvia Lima Costa
Journal:  Molecules       Date:  2020-07-27       Impact factor: 4.411

Review 6.  3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade.

Authors:  Maria J Matos; Eugenio Uriarte; Lourdes Santana
Journal:  Molecules       Date:  2021-11-08       Impact factor: 4.411

7.  Diverse and efficient catalytic applications of new cockscomb flower-like Fe3O4@SiO2@KCC-1@MPTMS@CuII mesoporous nanocomposite in the environmentally benign reduction and reductive acetylation of nitroarenes and one-pot synthesis of some coumarin compounds.

Authors:  Morteza Hasanpour Galehban; Behzad Zeynizadeh; Hossein Mousavi
Journal:  RSC Adv       Date:  2022-04-20       Impact factor: 4.036

8.  Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid.

Authors:  Rakesh R Chavan; Kallappa M Hosamani
Journal:  R Soc Open Sci       Date:  2018-05-02       Impact factor: 2.963
  8 in total

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