Michael L Alosco1, Ronald Cohen2, Mary Beth Spitznagel1, Gladys Strain3, Michael Devlin4, Ross D Crosby5, James E Mitchell5, John Gunstad6. 1. Kent State University, Kent, Ohio. 2. University of Florida Institute on Aging, Gainesville, Florida. 3. Weill Cornell Medical College, New York, New York. 4. Columbia University Medical Center, New York, New York. 5. University of North Dakota School of Medicine and Health Sciences and Neuropsychiatric Research Institute, Fargo, North Dakota. 6. Kent State University, Kent, Ohio. Electronic address: jgunstad@kent.edu.
Abstract
BACKGROUND: Bariatric surgery is associated with cognitive benefits, but the nature of such gains may be variable across demographically and clinically diverse persons. Older adults achieve less weight loss and resolution of fewer medical co-morbidities after surgery compared to younger patients and are also at heightened risk for nutritional deficiencies. However, no study has examined the influence of age on cognitive improvements after bariatric surgery. The objective of this study was to determine the effects of age on cognitive function postbariatric surgery. METHODS: A total of 95 participants enrolled in the Longitudinal Assessment for Bariatric Surgery completed a computerized cognitive test battery before bariatric surgery and at 12-weeks and 12-months postoperatively. RESULTS: Baseline cognitive impairments were common. Significant improvements were found in attention/executive function and memory abilities 12-weeks and 12-months after surgery. Age was not associated with baseline cognitive test performance. Separate multivariable regression analyses controlling for baseline attention/executive function and memory also showed that age was not a significant predictor of 12-week or 12-month performances in these domains (P>.05 for all). CONCLUSION: The present study provides preliminary evidence suggesting that older age does not preclude postbariatric surgery cognitive benefits. Prospective studies in more age diverse samples (i.e., up to 70 yr) are needed to determine whether bariatric surgery can reduce risk of age-related neurologic conditions like Alzheimer's disease and stroke.
BACKGROUND: Bariatric surgery is associated with cognitive benefits, but the nature of such gains may be variable across demographically and clinically diverse persons. Older adults achieve less weight loss and resolution of fewer medical co-morbidities after surgery compared to younger patients and are also at heightened risk for nutritional deficiencies. However, no study has examined the influence of age on cognitive improvements after bariatric surgery. The objective of this study was to determine the effects of age on cognitive function postbariatric surgery. METHODS: A total of 95 participants enrolled in the Longitudinal Assessment for Bariatric Surgery completed a computerized cognitive test battery before bariatric surgery and at 12-weeks and 12-months postoperatively. RESULTS: Baseline cognitive impairments were common. Significant improvements were found in attention/executive function and memory abilities 12-weeks and 12-months after surgery. Age was not associated with baseline cognitive test performance. Separate multivariable regression analyses controlling for baseline attention/executive function and memory also showed that age was not a significant predictor of 12-week or 12-month performances in these domains (P>.05 for all). CONCLUSION: The present study provides preliminary evidence suggesting that older age does not preclude postbariatric surgery cognitive benefits. Prospective studies in more age diverse samples (i.e., up to 70 yr) are needed to determine whether bariatric surgery can reduce risk of age-related neurologic conditions like Alzheimer's disease and stroke.
Authors: Steven H Belle; Paul D Berk; Anita P Courcoulas; David R Flum; Carolyn W Miles; James E Mitchell; Walter J Pories; Bruce M Wolfe; Susan Z Yanovski Journal: Surg Obes Relat Dis Date: 2007 Mar-Apr Impact factor: 4.734
Authors: Vanessa V Dos Santos; Ana Lúcia S Rodrigues; Thereza C De Lima; Susana R de Barioglio; Rita Raisman-Vozari; Rui D Prediger Journal: Curr Pharm Des Date: 2013 Impact factor: 3.116
Authors: Kelly M Stanek; Gladys Strain; Michael Devlin; Ronald Cohen; Robert Paul; Ross D Crosby; James E Mitchell; John Gunstad Journal: Neuropsychology Date: 2013-03 Impact factor: 3.295
Authors: Michael L Alosco; Mary Beth Spitznagel; Gladys Strain; Michael Devlin; Ross D Crosby; James E Mitchell; John Gunstad Journal: SAGE Open Med Date: 2014-06-17