| Literature DB >> 23530516 |
Vanessa V Dos Santos1, Ana Lúcia S Rodrigues, Thereza C De Lima, Susana R de Barioglio, Rita Raisman-Vozari, Rui D Prediger.
Abstract
Ghrelin is a gastric hormone that stimulates growth hormone (GH) secretion and food intake to regulate energy homeostasis and body weight by binding to its receptor, GH secretagogue receptor (GHSR1a), which is most highly expressed in the pituitary and hypothalamus. Nowadays there is considerable evidence showing that the GHSR1a is also expressed in numerous extra-hypothalamic neuronal populations and the physiological role of ghrelin is by far wider than considered before including learning and memory, anxiety, depression and neuroprotection. The present review attempts to provide a comprehensive picture of the role of ghrelin in the central nervous system and to highlight recent findings showing its potential as an innovative therapeutic agent in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.Entities:
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Year: 2013 PMID： 23530516 DOI： 10.2174/13816128113199990411
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116