BACKGROUND: Studies of conversion from mild cognitive impairment to dementia suggest a linear progression over time. Conversion rates during lifetime may extend to 80-90%. AIMS: This study examines the time-dependent evolution from mild cognitive impairment to dementia. Current assumptions regarding yearly and lifetime conversion rates are challenged. METHOD: A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing based on 6 years of observation. RESULTS: Approximately 60-65% of people with mild cognitive impairment develop clinical dementia during their life. Progression from mild cognitive impairment to dementia appears to be time dependent, occurring primarily within the initial 18 months. CONCLUSIONS: Further long-term studies are needed to examine the time-dependent evolution from mild cognitive impairment to dementia and to establish age-specific conversion rates during lifetime.
BACKGROUND: Studies of conversion from mild cognitive impairment to dementia suggest a linear progression over time. Conversion rates during lifetime may extend to 80-90%. AIMS: This study examines the time-dependent evolution from mild cognitive impairment to dementia. Current assumptions regarding yearly and lifetime conversion rates are challenged. METHOD: A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing based on 6 years of observation. RESULTS: Approximately 60-65% of people with mild cognitive impairment develop clinical dementia during their life. Progression from mild cognitive impairment to dementia appears to be time dependent, occurring primarily within the initial 18 months. CONCLUSIONS: Further long-term studies are needed to examine the time-dependent evolution from mild cognitive impairment to dementia and to establish age-specific conversion rates during lifetime.
Authors: Andrea C Tricco; Charlene Soobiah; Shirra Berliner; Joanne M Ho; Carmen H Ng; Huda M Ashoor; Maggie H Chen; Brenda Hemmelgarn; Sharon E Straus Journal: CMAJ Date: 2013-09-16 Impact factor: 8.262
Authors: Hanna Kaduszkiewicz; Marion Eisele; Birgitt Wiese; Jana Prokein; Melanie Luppa; Tobias Luck; Frank Jessen; Horst Bickel; Edelgard Mösch; Michael Pentzek; Angela Fuchs; Sandra Eifflaender-Gorfer; Siegfried Weyerer; Hans-Helmut König; Christian Brettschneider; Hendrik van den Bussche; Wolfgang Maier; Martin Scherer; Steffi G Riedel-Heller Journal: Ann Fam Med Date: 2014 Mar-Apr Impact factor: 5.166
Authors: Linda Lee; W Wayne Weston; George Heckman; Micheline Gagnon; F Joseph Lee; Scott Sloka Journal: Can Fam Physician Date: 2013-03 Impact factor: 3.275