Jed T Elison1, Jason J Wolff2, J Steven Reznick3, Kelly N Botteron4, Annette M Estes5, Hongbin Gu2, Heather C Hazlett2, Adriane J Meadows2, Sarah J Paterson6, Lonnie Zwaigenbaum7, Joseph Piven2. 1. Institute of Child Development at the University of Minnesota, Minneapolis. Electronic address: jtelison@umn.edu. 2. Carolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC. 3. University of North Carolina at Chapel Hill. 4. Washington University in St. Louis. 5. University of Washington, Seattle. 6. Dr. Paterson is with the Children's Hospital of Philadelphia. 7. Dr. Zwaigenbaum is with the University of Alberta, Edmonton, Alberta, Canada.
Abstract
OBJECTIVE: As compared to the utility of early emerging social communicative risk markers for predicting a later diagnosis of autism spectrum disorder (ASD), less is known about the relevance of early patterns of restricted and repetitive behaviors. We examined patterns of stereotyped motor mannerisms and repetitive manipulation of objects in 12-month-olds at high and low risk for developing ASD, all of whom were assessed for ASD at 24 months. METHOD: Observational coding of repetitive object manipulation and stereotyped motor behaviors in digital recordings of the Communication and Symbolic Behavior Scales was conducted using the Repetitive and Stereotyped Movement Scales for 3 groups of 12-month-olds: low-risk infants (LR, n = 53); high-familial-risk infants who did not meet diagnostic criteria for ASD at 24 months (HR-negative, n = 75); and high-familial-risk infants who met diagnostic criteria for ASD at 24 months (HR-ASD, n = 30). RESULTS: The HR-ASD group showed significantly more stereotyped motor mannerisms than both the HR-negative group (p = .025) and the LR group (p = .001). The HR-ASD and HR-negative groups demonstrated statistically equivalent repetitive object manipulation scores (p = .431), and both groups showed significantly more repetitive object manipulation than the LR group (p < .040). Combining the motor and object stereotypy scores into a Repetitive and Stereotyped Movement Scales (RSMS) composite yielded a disorder-continuum effect such that each group was significantly different from one another (LR < HR-negative < HR-ASD). CONCLUSION: These results suggest that targeted assessment of repetitive behavior during infancy may augment early ASD identification efforts.
OBJECTIVE: As compared to the utility of early emerging social communicative risk markers for predicting a later diagnosis of autism spectrum disorder (ASD), less is known about the relevance of early patterns of restricted and repetitive behaviors. We examined patterns of stereotyped motor mannerisms and repetitive manipulation of objects in 12-month-olds at high and low risk for developing ASD, all of whom were assessed for ASD at 24 months. METHOD: Observational coding of repetitive object manipulation and stereotyped motor behaviors in digital recordings of the Communication and Symbolic Behavior Scales was conducted using the Repetitive and Stereotyped Movement Scales for 3 groups of 12-month-olds: low-risk infants (LR, n = 53); high-familial-risk infants who did not meet diagnostic criteria for ASD at 24 months (HR-negative, n = 75); and high-familial-risk infants who met diagnostic criteria for ASD at 24 months (HR-ASD, n = 30). RESULTS: The HR-ASD group showed significantly more stereotyped motor mannerisms than both the HR-negative group (p = .025) and the LR group (p = .001). The HR-ASD and HR-negative groups demonstrated statistically equivalent repetitive object manipulation scores (p = .431), and both groups showed significantly more repetitive object manipulation than the LR group (p < .040). Combining the motor and object stereotypy scores into a Repetitive and Stereotyped Movement Scales (RSMS) composite yielded a disorder-continuum effect such that each group was significantly different from one another (LR < HR-negative < HR-ASD). CONCLUSION: These results suggest that targeted assessment of repetitive behavior during infancy may augment early ASD identification efforts.
Authors: Jason J Wolff; Kelly N Botteron; Stephen R Dager; Jed T Elison; Annette M Estes; Hongbin Gu; Heather C Hazlett; Juhi Pandey; Sarah J Paterson; Robert T Schultz; Lonnie Zwaigenbaum; Joseph Piven Journal: J Child Psychol Psychiatry Date: 2014-02-19 Impact factor: 8.982
Authors: Claire J McKinnon; Adam T Eggebrecht; Alexandre Todorov; Jason J Wolff; Jed T Elison; Chloe M Adams; Abraham Z Snyder; Annette M Estes; Lonnie Zwaigenbaum; Kelly N Botteron; Robert C McKinstry; Natasha Marrus; Alan Evans; Heather C Hazlett; Stephen R Dager; Sarah J Paterson; Juhi Pandey; Robert T Schultz; Martin A Styner; Guido Gerig; Bradley L Schlaggar; Steven E Petersen; Joseph Piven; John R Pruett Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-10-02
Authors: Meghan R Swanson; Mark D Shen; Jason J Wolff; Brian Boyd; Mark Clements; James Rehg; Jed T Elison; Sarah Paterson; Julia Parish-Morris; J Chad Chappell; Heather C Hazlett; Robert W Emerson; Kelly Botteron; Juhi Pandey; Robert T Schultz; Stephen R Dager; Lonnie Zwaigenbaum; Annette M Estes; Joseph Piven Journal: Child Dev Date: 2017-03-10
Authors: Jason J Wolff; Kelly N Botteron; Stephen R Dager; Jed T Elison; Annette M Estes; Hongbin Gu; Heather C Hazlett; Juhi Pandey; Sarah J Paterson; Robert T Schultz; Lonnie Zwaigenbaum; Joseph Piven Journal: J Child Psychol Psychiatry Date: 2014-02-19 Impact factor: 8.982
Authors: Kaitlyn P Wilson; Mary W Carter; Heather L Wiener; Margaret L DeRamus; John C Bulluck; Linda R Watson; Elizabeth R Crais; Grace T Baranek Journal: Autism Dev Lang Impair Date: 2017-06-15
Authors: Jason J Wolff; Adele F Dimian; Kelly N Botteron; Stephen R Dager; Jed T Elison; Annette M Estes; Heather C Hazlett; Robert T Schultz; Lonnie Zwaigenbaum; Joseph Piven Journal: J Child Psychol Psychiatry Date: 2018-10-23 Impact factor: 8.982