| Literature DB >> 25438306 |
R Matthew Ferguson, Amit P Khandhar, Scott J Kemp, Hamed Arami, Emine U Saritas, Laura R Croft, Justin Konkle, Patrick W Goodwill, Aleksi Halkola, Jurgen Rahmer, Jorn Borgert, Steven M Conolly, Kannan M Krishnan.
Abstract
Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2(∗) -weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3 × greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.Entities:
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Year: 2014 PMID： 25438306 PMCID： PMC4428902 DOI： 10.1109/TMI.2014.2375065
Source DB: PubMed Journal: IEEE Trans Med Imaging ISSN： 0278-0062 Impact factor: 10.048