Jeff W M Bulte1. 1. Russell H. Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jwmbulte@mri.jhu.edu
Abstract
OBJECTIVE: The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION: Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
OBJECTIVE: The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION: Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
Authors: Charles H Cunningham; Takayasu Arai; Phillip C Yang; Michael V McConnell; John M Pauly; Steven M Conolly Journal: Magn Reson Med Date: 2005-05 Impact factor: 4.668
Authors: Matthias Stuber; Wesley D Gilson; Michael Schär; Dorota A Kedziorek; Lawrence V Hofmann; Saurabh Shah; Evert-Jan Vonken; Jeff W M Bulte; Dara L Kraitchman Journal: Magn Reson Med Date: 2007-11 Impact factor: 4.668
Authors: A M James Shapiro; Camillo Ricordi; Bernhard J Hering; Hugh Auchincloss; Robert Lindblad; R Paul Robertson; Antonio Secchi; Mathias D Brendel; Thierry Berney; Daniel C Brennan; Enrico Cagliero; Rodolfo Alejandro; Edmond A Ryan; Barbara DiMercurio; Philippe Morel; Kenneth S Polonsky; Jo-Anna Reems; Reinhard G Bretzel; Federico Bertuzzi; Tatiana Froud; Raja Kandaswamy; David E R Sutherland; George Eisenbarth; Miriam Segal; Jutta Preiksaitis; Gregory S Korbutt; Franca B Barton; Lisa Viviano; Vicki Seyfert-Margolis; Jeffrey Bluestone; Jonathan R T Lakey Journal: N Engl J Med Date: 2006-09-28 Impact factor: 91.245
Authors: C Toso; J-P Vallee; P Morel; F Ris; S Demuylder-Mischler; M Lepetit-Coiffe; N Marangon; F Saudek; A M James Shapiro; D Bosco; T Berney Journal: Am J Transplant Date: 2008-03 Impact factor: 8.086
Authors: J W Bulte; Y Hoekstra; R L Kamman; R L Magin; A G Webb; R W Briggs; K G Go; C E Hulstaert; S Miltenyi; T H The Journal: Magn Reson Med Date: 1992-05 Impact factor: 4.668
Authors: Stacey Cromer Berman; Chulani Galpoththawela; Assaf A Gilad; Jeff W M Bulte; Piotr Walczak Journal: Magn Reson Med Date: 2010-10-06 Impact factor: 4.668
Authors: A Abarrategi; M E Fernandez-Valle; T Desmet; D Castejón; A Civantos; C Moreno-Vicente; V Ramos; J V Sanz-Casado; F J Martínez-Vázquez; P Dubruel; P Miranda; J L López-Lacomba Journal: J R Soc Interface Date: 2012-03-22 Impact factor: 4.118
Authors: Dorota A Kedziorek; Naser Muja; Piotr Walczak; Jesus Ruiz-Cabello; Assaf A Gilad; Chunfa C Jie; Jeff W M Bulte Journal: Magn Reson Med Date: 2010-04 Impact factor: 4.668
Authors: Yaohui Tang; Chunfu Zhang; Jixian Wang; Xiaojie Lin; Lu Zhang; Yi Yang; Yongting Wang; Zhijun Zhang; Jeff W M Bulte; Guo-Yuan Yang Journal: Adv Funct Mater Date: 2015-02-18 Impact factor: 18.808
Authors: Dian R Arifin; Dorota A Kedziorek; Yingli Fu; Kannie W Y Chan; Michael T McMahon; Clifford R Weiss; Dara L Kraitchman; Jeff W M Bulte Journal: NMR Biomed Date: 2012-12-07 Impact factor: 4.044