Literature DB >> 25428159

A new type of toxin A-negative, toxin B-positive Clostridium difficile strain lacking a complete tcdA gene.

Sandra Janezic1, Mercedes Marín2, Adoración Martín2, Maja Rupnik3.   

Abstract

Toxins A and B are the main virulence factors of Clostridium difficile and are the targets for molecular diagnostic tests. Here, we describe a new toxin A-negative, toxin B-positive, binary toxin CDT (Clostridium difficile transferase)-negative (A(-) B(+) CDT(-)) toxinotype (XXXII) characterized by a variant type of pathogenicity locus (PaLoc) without tcdA and with atypical organization of the PaLoc integration site.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25428159      PMCID： PMC4298534          DOI： 10.1128/JCM.02211-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  16 in total

1.  New types of toxin A-negative, toxin B-positive strains among clinical isolates of Clostridium difficile in Australia.

Authors:  Briony Elliott; Michelle M Squire; Sara Thean; Barbara J Chang; Jon S Brazier; Maja Rupnik; Thomas V Riley
Journal:  J Med Microbiol       Date:  2011-03-10       Impact factor: 2.472

2.  Clostridium difficile toxinotyping.

Authors:  Maja Rupnik
Journal:  Methods Mol Biol       Date:  2010

3.  Vital signs: preventing Clostridium difficile infections.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2012-03-09       Impact factor: 17.586

Review 4.  Tests for the diagnosis of Clostridium difficile infection: the next generation.

Authors:  Karen C Carroll
Journal:  Anaerobe       Date:  2011-03-03       Impact factor: 3.331

5.  Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (Toxin A), and tcdB (Toxin B) genes for toxigenic culture of Clostridium difficile.

Authors:  Ludovic Lemee; Anne Dhalluin; Sabrina Testelin; Marie-Andre Mattrat; Karine Maillard; Jean-François Lemeland; Jean-Louis Pons
Journal:  J Clin Microbiol       Date:  2004-12       Impact factor: 5.948

6.  Definition of the single integration site of the pathogenicity locus in Clostridium difficile.

Authors:  V Braun; T Hundsberger; P Leukel; M Sauerborn; C von Eichel-Streiber
Journal:  Gene       Date:  1996-11-28       Impact factor: 3.688

7.  Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates.

Authors:  Patrizia Spigaglia; Paola Mastrantonio
Journal:  J Clin Microbiol       Date:  2002-09       Impact factor: 5.948

Review 8.  European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI).

Authors:  M J T Crobach; O M Dekkers; M H Wilcox; E J Kuijper
Journal:  Clin Microbiol Infect       Date:  2009-12       Impact factor: 8.067

Review 9.  Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance.

Authors:  Dale N Gerding; Stuart Johnson; Maja Rupnik; Klaus Aktories
Journal:  Gut Microbes       Date:  2013-10-31

10.  Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia.

Authors:  Michele M Squire; Glen P Carter; Kate E Mackin; Anjana Chakravorty; Torbjörn Norén; Briony Elliott; Dena Lyras; Thomas V Riley
Journal:  Emerg Infect Dis       Date:  2013-05       Impact factor: 6.883
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  15 in total

1.  A small-molecule antivirulence agent for treating Clostridium difficile infection.

Authors:  Kristina Oresic Bender; Megan Garland; Jessica A Ferreyra; Andrew J Hryckowian; Matthew A Child; Aaron W Puri; David E Solow-Cordero; Steven K Higginbottom; Ehud Segal; Niaz Banaei; Aimee Shen; Justin L Sonnenburg; Matthew Bogyo
Journal:  Sci Transl Med       Date:  2015-09-23       Impact factor: 17.956

Review 2.  An Update on Clostridium difficile Toxinotyping.

Authors:  Maja Rupnik; Sandra Janezic
Journal:  J Clin Microbiol       Date:  2015-10-28       Impact factor: 5.948

3.  Detection of Clostridium difficile in Feces of Asymptomatic Patients Admitted to the Hospital.

Authors:  Elisabeth M Terveer; Monique J T Crobach; Ingrid M J G Sanders; Margreet C Vos; Cees M Verduin; Ed J Kuijper
Journal:  J Clin Microbiol       Date:  2016-11-16       Impact factor: 5.948

4.  Highly Divergent Clostridium difficile Strains Isolated from the Environment.

Authors:  Sandra Janezic; Mojca Potocnik; Valerija Zidaric; Maja Rupnik
Journal:  PLoS One       Date:  2016-11-23       Impact factor: 3.240

5.  Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets.

Authors:  Sara Andrés-Lasheras; Inma Martín-Burriel; Raúl Carlos Mainar-Jaime; Mariano Morales; Ed Kuijper; José L Blanco; Manuel Chirino-Trejo; Rosa Bolea
Journal:  BMC Vet Res       Date:  2018-03-09       Impact factor: 2.741

6.  Molecular Detection of Toxigenic Clostridioides difficile among Diarrheic Dogs and Cats: A Mounting Public Health Concern.

Authors:  Ahmed Samir; Khaled A Abdel-Moein; Hala M Zaher
Journal:  Vet Sci       Date:  2021-05-22

Review 7.  Large Clostridial Toxins: Mechanisms and Roles in Disease.

Authors:  Kathleen E Orrell; Roman A Melnyk
Journal:  Microbiol Mol Biol Rev       Date:  2021-06-02       Impact factor: 13.044

8.  Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus.

Authors:  Marc Monot; Catherine Eckert; Astrid Lemire; Audrey Hamiot; Thomas Dubois; Carine Tessier; Bruno Dumoulard; Benjamin Hamel; Amandine Petit; Valérie Lalande; Laurence Ma; Christiane Bouchier; Frédéric Barbut; Bruno Dupuy
Journal:  Sci Rep       Date:  2015-10-08       Impact factor: 4.379

Review 9.  The Regulatory Networks That Control Clostridium difficile Toxin Synthesis.

Authors:  Isabelle Martin-Verstraete; Johann Peltier; Bruno Dupuy
Journal:  Toxins (Basel)       Date:  2016-05-14       Impact factor: 4.546

Review 10.  Advances in the Microbiome: Applications to Clostridium difficile Infection.

Authors:  Eamonn P Culligan; Roy D Sleator
Journal:  J Clin Med       Date:  2016-09-21       Impact factor: 4.241
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