Literature DB >> 20597003

Clostridium difficile toxinotyping.

Maja Rupnik1.   

Abstract

Clostridium difficile shows considerable variability in the PaLoc region encoding two main virulence factors, toxins TcdA and TcdB. Strains with changes in PaLoc are defined as variant toxinotypes and currently 27 such groups are recognized (I to XXVII). Toxinotype 0 includes strains with PaLoc identical to the reference laboratory strain VPI 10463. Toxinotyping is a RFLP-PCR-based method using a combination of restriction patterns of part of tcdB and tcdA genes for determination of toxinotype. Variations in PaLoc can affect the toxin production or could result in production of toxins with altered properties.

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Year:  2010        PMID： 20597003     DOI： 10.1007/978-1-60327-365-7_5

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  15 in total

1.  The Detection Rate of Enteric Viruses and Clostridium difficile in a Waste Water Treatment Plant Effluent.

Authors:  Andrej Steyer; Ion Gutiérrez-Aguirre; Nejc Rački; Sara Beigot Glaser; Barbara Brajer Humar; Marjeta Stražar; Igor Škrjanc; Mateja Poljšak-Prijatelj; Maja Ravnikar; Maja Rupnik
Journal:  Food Environ Virol       Date:  2015-02-07       Impact factor: 2.778

2.  Toxin-positive Clostridium difficile latently infect mouse colonies and protect against highly pathogenic C. difficile.

Authors:  Lucie Etienne-Mesmin; Benoit Chassaing; Oluwaseyi Adekunle; Lisa M Mattei; Frederic D Bushman; Andrew T Gewirtz
Journal:  Gut       Date:  2017-02-20       Impact factor: 23.059

3.  Sequence variation in tcdA and tcdB of Clostridium difficile: ST37 with truncated tcdA is a potential epidemic strain in China.

Authors:  Pengcheng Du; Bo Cao; Jing Wang; Wenge Li; Hongbing Jia; Wen Zhang; Jinxing Lu; Zhongjie Li; Hongjie Yu; Chen Chen; Ying Cheng
Journal:  J Clin Microbiol       Date:  2014-06-23       Impact factor: 5.948

Review 4.  An Update on Clostridium difficile Toxinotyping.

Authors:  Maja Rupnik; Sandra Janezic
Journal:  J Clin Microbiol       Date:  2015-10-28       Impact factor: 5.948

Review 5.  Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories.

Authors:  Carey-Ann D Burnham; Karen C Carroll
Journal:  Clin Microbiol Rev       Date:  2013-07       Impact factor: 26.132

6.  A new type of toxin A-negative, toxin B-positive Clostridium difficile strain lacking a complete tcdA gene.

Authors:  Sandra Janezic; Mercedes Marín; Adoración Martín; Maja Rupnik
Journal:  J Clin Microbiol       Date:  2014-11-26       Impact factor: 5.948

7.  Using phenotype microarrays to determine culture conditions that induce or repress toxin production by Clostridium difficile and other microorganisms.

Authors:  Xiang-He Lei; Barry R Bochner
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

8.  Clostridioides difficile positivity rate and PCR ribotype distribution on retail potatoes in 12 European countries, January to June 2018.

Authors:  Valerija Tkalec; Virginie Viprey; Georgina Davis; Sandra Janezic; Béatrice Sente; Nathalie Devos; Mark Wilcox; Kerrie Davies; Maja Rupnik
Journal:  Euro Surveill       Date:  2022-04

9.  Clostridium difficile in faeces from healthy dogs and dogs with diarrhea.

Authors:  Karl-Johan Wetterwik; Gunilla Trowald-Wigh; Lise-Lotte Fernström; Karel Krovacek
Journal:  Acta Vet Scand       Date:  2013-03-12       Impact factor: 1.695

10.  Epidemic Clostridium difficile ribotype 027 in Chile.

Authors:  Cristian Hernández-Rocha; Jonathan Barra-Carrasco; Marjorie Pizarro-Guajardo; Patricio Ibáñez; Susan M Bueno; Mahfuzur R Sarker; Ana María Guzman; Manuel Alvarez-Lobos; Daniel Paredes-Sabja
Journal:  Emerg Infect Dis       Date:  2012-08       Impact factor: 6.883
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