BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire. Logistic regression models were used to estimate PC risk. RESULTS: In multivariable analyzes, higher carbohydrate intake, measured as percent of energy from carbohydrates, was associated with reduced PC risk (3rd vs. 1st tertile, OR = 0.41, 95% CI 0.21-0.81, P = 0.010), though this only reached significance in white men (p-trend = 0.029). GI was unrelated to PC risk among all men, but suggestively linked with reduced PC risk in white men (p-trend = 0.066) and increased PC risk in black men (p-trend = 0.172), however, the associations were not significant. Fiber intake was not associated with PC risk (all p-trends > 0.55). Higher carbohydrate intake was associated with reduced risk of high-grade (p-trend = 0.016), but not low-grade PC (p-trend = 0.593). CONCLUSION: Higher carbohydrate intake may be associated with reduced risk of overall and high-grade PC. Future larger studies are needed to confirm these findings.
BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire. Logistic regression models were used to estimate PC risk. RESULTS: In multivariable analyzes, higher carbohydrate intake, measured as percent of energy from carbohydrates, was associated with reduced PC risk (3rd vs. 1st tertile, OR = 0.41, 95% CI 0.21-0.81, P = 0.010), though this only reached significance in white men (p-trend = 0.029). GI was unrelated to PC risk among all men, but suggestively linked with reduced PC risk in white men (p-trend = 0.066) and increased PC risk in black men (p-trend = 0.172), however, the associations were not significant. Fiber intake was not associated with PC risk (all p-trends > 0.55). Higher carbohydrate intake was associated with reduced risk of high-grade (p-trend = 0.016), but not low-grade PC (p-trend = 0.593). CONCLUSION: Higher carbohydrate intake may be associated with reduced risk of overall and high-grade PC. Future larger studies are needed to confirm these findings.
Authors: Abhay A Singh; Lee W Jones; Jodi A Antonelli; Leah Gerber; Elizabeth E Calloway; Kathleen H Shuler; Stephen J Freedland; Delores J Grant; Cathrine Hoyo; Lionel L Bañez Journal: Cancer Date: 2013-02-11 Impact factor: 6.860
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Leslie K Dennis; Linda G Snetselaar; Brian J Smith; Ron E Stewart; Michael E C Robbins Journal: Am J Epidemiol Date: 2004-09-01 Impact factor: 4.897
Authors: S M Haffner; R D'Agostino; M F Saad; M Rewers; L Mykkänen; J Selby; G Howard; P J Savage; R F Hamman; L E Wagenknecht Journal: Diabetes Date: 1996-06 Impact factor: 9.461
Authors: Theodore M Brasky; Amy K Darke; Xiaoling Song; Catherine M Tangen; Phyllis J Goodman; Ian M Thompson; Frank L Meyskens; Gary E Goodman; Lori M Minasian; Howard L Parnes; Eric A Klein; Alan R Kristal Journal: J Natl Cancer Inst Date: 2013-07-10 Impact factor: 13.506
Authors: Francesca L Crowe; Naomi E Allen; Paul N Appleby; Kim Overvad; Inge V Aardestrup; Nina F Johnsen; Anne Tjønneland; Jakob Linseisen; Rudolf Kaaks; Heiner Boeing; Janine Kröger; Antonia Trichopoulou; Assimina Zavitsanou; Dimitrios Trichopoulos; Carlotta Sacerdote; Domenico Palli; Rosario Tumino; Claudia Agnoli; Lambertus A Kiemeney; H Bas Bueno-de-Mesquita; María-Dolores Chirlaque; Eva Ardanaz; Nerea Larrañaga; José R Quirós; Maria-José Sánchez; Carlos A González; Pär Stattin; Göran Hallmans; Sheila Bingham; Kay-Tee Khaw; Sabina Rinaldi; Nadia Slimani; Mazda Jenab; Elio Riboli; Timothy J Key Journal: Am J Clin Nutr Date: 2008-11 Impact factor: 7.045
Authors: Fred Tabung; Susan E Steck; L Joseph Su; James L Mohler; Elizabeth T H Fontham; Jeannette T Bensen; James R Hebert; Hongmei Zhang; Lenore Arab Journal: Prostate Cancer Date: 2012-11-13
Authors: Kyeezu Kim; Angela Kong; Robert C Flanigan; Marcus L Quek; Courtney M P Hollowell; Patricia P Vidal; Jefferey Branch; Leslie A Dean; Virgilia Macias; Andre A Kajadacsy-Balla; Marian L Fitzgibbon; Daisy Cintron; Li Liu; Vincent L Freeman Journal: Cancer Causes Control Date: 2019-02-07 Impact factor: 2.506