BACKGROUND: Plausible biological mechanisms underlie possible associations between fatty acids in blood and risk of prostate cancer; epidemiologic evidence for an association, however, is inconsistent. OBJECTIVE: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. DESIGN: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. The fatty acid composition of plasma phospholipids was measured by gas chromatography, and the risk of prostate cancer was estimated by using conditional logistic regression with adjustment for lifestyle variables. RESULTS: We found a positive association between palmitic acid and risk of total, localized, and low-grade prostate cancer. The risk of prostate cancer for men in the highest quintile compared with the lowest quintile of palmitic acid was 1.47 (95% CI: 0.97, 2.23; P for trend = 0.032). We found an inverse association between stearic acid and the risk of total, localized, and low-grade prostate cancer; men in the highest quintile of stearic acid had a relative risk of 0.77 (95% CI: 0.56, 1.06; P for trend = 0.03). There were significant positive associations between myristic, alpha-linolenic, and eicosapentaenoic acids and risk of high-grade prostate cancer. CONCLUSION: The associations between palmitic, stearic, myristic, alpha-linolenic, and eicosapentaenoic acids and prostate cancer risk may reflect differences in intake or metabolism of these fatty acids between the precancer cases and controls and should be explored further.
BACKGROUND: Plausible biological mechanisms underlie possible associations between fatty acids in blood and risk of prostate cancer; epidemiologic evidence for an association, however, is inconsistent. OBJECTIVE: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. DESIGN: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. The fatty acid composition of plasma phospholipids was measured by gas chromatography, and the risk of prostate cancer was estimated by using conditional logistic regression with adjustment for lifestyle variables. RESULTS: We found a positive association between palmitic acid and risk of total, localized, and low-grade prostate cancer. The risk of prostate cancer for men in the highest quintile compared with the lowest quintile of palmitic acid was 1.47 (95% CI: 0.97, 2.23; P for trend = 0.032). We found an inverse association between stearic acid and the risk of total, localized, and low-grade prostate cancer; men in the highest quintile of stearic acid had a relative risk of 0.77 (95% CI: 0.56, 1.06; P for trend = 0.03). There were significant positive associations between myristic, alpha-linolenic, and eicosapentaenoic acids and risk of high-grade prostate cancer. CONCLUSION: The associations between palmitic, stearic, myristic, alpha-linolenic, and eicosapentaenoic acids and prostate cancer risk may reflect differences in intake or metabolism of these fatty acids between the precancer cases and controls and should be explored further.
Authors: Theodore M Brasky; Cathee Till; Emily White; Marian L Neuhouser; Xiaoling Song; Phyllis Goodman; Ian M Thompson; Irena B King; Demetrius Albanes; Alan R Kristal Journal: Am J Epidemiol Date: 2011-04-24 Impact factor: 4.897
Authors: Lisa M Butler; Ylenia Perone; Jonas Dehairs; Leslie E Lupien; Vincent de Laat; Ali Talebi; Massimo Loda; William B Kinlaw; Johannes V Swinnen Journal: Adv Drug Deliv Rev Date: 2020-07-23 Impact factor: 15.470
Authors: Meng Yang; Azalea Ayuningtyas; Stacey A Kenfield; Howard D Sesso; Hannia Campos; Jing Ma; Meir J Stampfer; Jorge E Chavarro Journal: Cancer Causes Control Date: 2016-08-03 Impact factor: 2.506
Authors: Sarah H Nash; Jeannette M Schenk; Alan R Kristal; Phillis J Goodman; M Scott Lucia; Howard L Parnes; Ian M Thompson; Scott M Lippman; Xiaoling Song; Bora Gurel; Angelo De Marzo; Elizabeth A Platz Journal: Cancer Prev Res (Phila) Date: 2015-04-29
Authors: Colleen Pelser; Alison M Mondul; Albert R Hollenbeck; Yikyung Park Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-04 Impact factor: 4.254
Authors: Jorge E Chavarro; Stacey A Kenfield; Meir J Stampfer; Massimo Loda; Hannia Campos; Howard D Sesso; Jing Ma Journal: Am J Epidemiol Date: 2013-08-28 Impact factor: 4.897
Authors: Michael E Chua; Maria Christina D Sio; Mishell C Sorongon; Marcelino L Morales Journal: Can Urol Assoc J Date: 2013 May-Jun Impact factor: 1.862
Authors: Meng Yang; Howard D Sesso; Graham A Colditz; Jing Ma; Meir J Stampfer; Jorge E Chavarro Journal: J Natl Cancer Inst Date: 2016-06-13 Impact factor: 13.506