| Literature DB >> 25417168 |
Kristin A Anderson1, Michelle F Green2, Frank K Huynh2, Gregory R Wagner2, Matthew D Hirschey3.
Abstract
The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.Entities:
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Year: 2014 PMID： 25417168 PMCID： PMC4337867 DOI： 10.1016/j.cell.2014.10.045
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582