Literature DB >> 24213807

SIRT6, a protein with many faces.

Asaf A Gertler1, Haim Y Cohen.   

Abstract

Sirtuins are NAD(+) dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1-SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.

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Year:  2013        PMID： 24213807     DOI： 10.1007/s10522-013-9478-8

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  29 in total

1.  Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.

Authors:  Xin Shen; Xin Chen; Jiadong Huang; Rongyao Xu; Jie Cheng; Hongbing Jiang
Journal:  J Mol Histol       Date:  2020-01-30       Impact factor: 2.611

2.  A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.

Authors:  J Cai; Y Zuo; T Wang; Y Cao; R Cai; F-L Chen; J Cheng; J Mu
Journal:  Oncogene       Date:  2016-02-22       Impact factor: 9.867

Review 3.  Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Authors:  Luis Rajman; Karolina Chwalek; David A Sinclair
Journal:  Cell Metab       Date:  2018-03-06       Impact factor: 27.287

4.  The role of SIRT6 in tumors.

Authors:  Vanessa Desantis; Aurelia Lamanuzzi; Angelo Vacca
Journal:  Haematologica       Date:  2018-01       Impact factor: 9.941

5.  The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair.

Authors:  Muriel W Lambert
Journal:  Exp Biol Med (Maywood)       Date:  2019-10-04

6.  SnapShot: Mammalian Sirtuins.

Authors:  Kristin A Anderson; Michelle F Green; Frank K Huynh; Gregory R Wagner; Matthew D Hirschey
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

7.  N-Acylethanolamines Bind to SIRT6.

Authors:  Minna Rahnasto-Rilla; Tarja Kokkola; Elina Jarho; Maija Lahtela-Kakkonen; Ruin Moaddel
Journal:  Chembiochem       Date:  2015-11-26       Impact factor: 3.164

8.  Sirtuin 6 attenuates angiotensin II-induced vascular adventitial aging in rat aortae by suppressing the NF-κB pathway.

Authors:  Xiaoqian Liu; Dongyang Jiang; Wen Huang; Peixiu Teng; Hui Zhang; Chuanqiao Wei; Xiaowen Cai; Ying Liang
Journal:  Hypertens Res       Date:  2021-03-02       Impact factor: 3.872

9.  Roles of SIRT6 in kidney disease: a novel therapeutic target.

Authors:  Xueyan Yang; Jun Feng; Wei Liang; Zijing Zhu; Zhaowei Chen; Jijia Hu; Dingping Yang; Guohua Ding
Journal:  Cell Mol Life Sci       Date:  2021-12-24       Impact factor: 9.261

10.  Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.

Authors:  Sadhana A Samant; Vinodkumar B Pillai; Mahesh P Gupta
Journal:  JCSM Rapid Commun       Date:  2020-12-23
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