Literature DB >> 19641587

Recent progress in the biology and physiology of sirtuins.

Toren Finkel1, Chu-Xia Deng, Raul Mostoslavsky.   

Abstract

The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

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Year:  2009        PMID： 19641587      PMCID： PMC3727385          DOI： 10.1038/nature08197

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  84 in total

1.  Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

Authors:  Timour Prozorovski; Ulf Schulze-Topphoff; Robert Glumm; Jan Baumgart; Friederike Schröter; Olaf Ninnemann; Elise Siegert; Ivo Bendix; Oliver Brüstle; Robert Nitsch; Frauke Zipp; Orhan Aktas
Journal:  Nat Cell Biol       Date:  2008-03-16       Impact factor: 28.824

2.  A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Authors:  In Hye Lee; Liu Cao; Raul Mostoslavsky; David B Lombard; Jie Liu; Nicholas E Bruns; Maria Tsokos; Frederick W Alt; Toren Finkel
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-22       Impact factor: 11.205

3.  Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.

Authors:  Olesya Vakhrusheva; Christian Smolka; Praveen Gajawada; Sawa Kostin; Thomas Boettger; Thomas Kubin; Thomas Braun; Eva Bober
Journal:  Circ Res       Date:  2008-01-31       Impact factor: 17.367

4.  SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Authors:  Eriko Michishita; Ronald A McCord; Elisabeth Berber; Mitomu Kioi; Hesed Padilla-Nash; Mara Damian; Peggie Cheung; Rika Kusumoto; Tiara L A Kawahara; J Carl Barrett; Howard Y Chang; Vilhelm A Bohr; Thomas Ried; Or Gozani; Katrin F Chua
Journal:  Nature       Date:  2008-03-12       Impact factor: 49.962

5.  Epigenetic control of rDNA loci in response to intracellular energy status.

Authors:  Akiko Murayama; Kazuji Ohmori; Akiko Fujimura; Hiroshi Minami; Kayoko Yasuzawa-Tanaka; Takao Kuroda; Shohei Oie; Hiroaki Daitoku; Mitsuru Okuwaki; Kyosuke Nagata; Akiyoshi Fukamizu; Keiji Kimura; Toshiyuki Shimizu; Junn Yanagisawa
Journal:  Cell       Date:  2008-05-16       Impact factor: 41.582

6.  SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.

Authors:  Myung-Kwan Han; Eun-Kyung Song; Ying Guo; Xuan Ou; Charlie Mantel; Hal E Broxmeyer
Journal:  Cell Stem Cell       Date:  2008-03-06       Impact factor: 24.633

Review 7.  Sirtuins: novel targets for metabolic disease.

Authors:  Peter J Elliott; Michael Jirousek
Journal:  Curr Opin Investig Drugs       Date:  2008-04

8.  C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.

Authors:  Tjakko J van Ham; Karen L Thijssen; Rainer Breitling; Robert M W Hofstra; Ronald H A Plasterk; Ellen A A Nollen
Journal:  PLoS Genet       Date:  2008-03-21       Impact factor: 5.917

9.  The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Authors:  Ron Firestein; Gil Blander; Shaday Michan; Philipp Oberdoerffer; Shuji Ogino; Jennifer Campbell; Anupama Bhimavarapu; Sandra Luikenhuis; Rafael de Cabo; Charles Fuchs; William C Hahn; Leonard P Guarente; David A Sinclair
Journal:  PLoS One       Date:  2008-04-16       Impact factor: 3.240

10.  SirT1 regulates energy metabolism and response to caloric restriction in mice.

Authors:  Gino Boily; Erin L Seifert; Lisa Bevilacqua; Xiao Hong He; Guillaume Sabourin; Carmen Estey; Cynthia Moffat; Sean Crawford; Sarah Saliba; Karen Jardine; Jian Xuan; Meredith Evans; Mary-Ellen Harper; Michael W McBurney
Journal:  PLoS One       Date:  2008-03-12       Impact factor: 3.240
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  621 in total

Review 1.  Regulation of SIRT1 in cellular functions: role of polyphenols.

Authors:  Sangwoon Chung; Hongwei Yao; Samuel Caito; Jae-Woong Hwang; Gnanapragasam Arunachalam; Irfan Rahman
Journal:  Arch Biochem Biophys       Date:  2010-05-05       Impact factor: 4.013

2.  Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets.

Authors:  Pavan K Battiprolu; Thomas G Gillette; Zhao V Wang; Sergio Lavandero; Joseph A Hill
Journal:  Drug Discov Today Dis Mech       Date:  2010

Review 3.  Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.

Authors:  Nagalingam R Sundaresan; Vinodkumar B Pillai; Mahesh P Gupta
Journal:  J Mol Cell Cardiol       Date:  2011-01-27       Impact factor: 5.000

Review 4.  Evidence demonstrating role of microRNAs in the etiopathology of major depression.

Authors:  Yogesh Dwivedi
Journal:  J Chem Neuroanat       Date:  2011-04-14       Impact factor: 3.052

5.  Sirtuin activation: a role for plasma membrane in the cell growth puzzle.

Authors:  Frederick L Crane; Plácido Navas; Hans Low; Iris L Sun; Rafael de Cabo
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-10-02       Impact factor: 6.053

Review 6.  Regulation of autophagy and mitophagy by nutrient availability and acetylation.

Authors:  Bradley R Webster; Iain Scott; Javier Traba; Kim Han; Michael N Sack
Journal:  Biochim Biophys Acta       Date:  2014-02-11

7.  Obesity, insulin resistance, adipocytokines and breast cancer: New biomarkers and attractive therapeutic targets.

Authors:  Maria Dalamaga
Journal:  World J Exp Med       Date:  2013-08-20

Review 8.  The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p.

Authors:  Gianluca Serafini; Maurizio Pompili; Katelin F Hansen; Karl Obrietan; Yogesh Dwivedi; Noam Shomron; Paolo Girardi
Journal:  Cell Mol Neurobiol       Date:  2013-11-09       Impact factor: 5.046

Review 9.  Chromatin and beyond: the multitasking roles for SIRT6.

Authors:  Sita Kugel; Raul Mostoslavsky
Journal:  Trends Biochem Sci       Date:  2014-01-14       Impact factor: 13.807

10.  The enhanced apoptosis and antiproliferative response to combined treatment with valproate and nicotinamide in MCF-7 breast cancer cells.

Authors:  Hanieh Jafary; Shahin Ahmadian; Masoud Soleimani
Journal:  Tumour Biol       Date:  2013-11-10
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