| Literature DB >> 25414313 |
J M Fonville1,2,3, S H Wilks1,2, S L James1,2, A Fox4, M Ventresca1, M Aban5, L Xue5, T C Jones1,2, N M H Le4, Q T Pham6, N D Tran6, Y Wong7, A Mosterin1,2, L C Katzelnick1,2, D Labonte8, T T Le6, G van der Net3, E Skepner1,2, C A Russell2,9, T D Kaplan10, G F Rimmelzwaan3, N Masurel3, J C de Jong3, A Palache11, W E P Beyer3, Q M Le6, T H Nguyen6, H F L Wertheim4,12, A C Hurt5,13, A D M E Osterhaus3, I G Barr5, R A M Fouchier3, P W Horby4,12, D J Smith1,2,3.
Abstract
We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including previously encountered viruses far beyond the extent of cross-reactivity observed after a primary infection. We explored implications for vaccination and found that the use of an antigenically advanced virus had the dual benefit of inducing antibodies against both advanced and previous antigenic clusters. These results indicate that preemptive vaccine updates may improve influenza vaccine efficacy in previously exposed individuals.Entities:
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Year: 2014 PMID： 25414313 PMCID： PMC4246172 DOI： 10.1126/science.1256427
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728