| Literature DB >> 26383952 |
Leah C Katzelnick1, Judith M Fonville2, Gregory D Gromowski3, Jose Bustos Arriaga3, Angela Green4, Sarah L James5, Louis Lau4, Magelda Montoya4, Chunling Wang4, Laura A VanBlargan3, Colin A Russell6, Hlaing Myat Thu7, Theodore C Pierson3, Philippe Buchy8, John G Aaskov9, Jorge L Muñoz-Jordán10, Nikos Vasilakis11, Robert V Gibbons12, Robert B Tesh11, Albert D M E Osterhaus13, Ron A M Fouchier13, Anna Durbin14, Cameron P Simmons15, Edward C Holmes16, Eva Harris4, Stephen S Whitehead3, Derek J Smith17.
Abstract
The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.Entities:
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Year: 2015 PMID： 26383952 PMCID： PMC4876809 DOI： 10.1126/science.aac5017
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728