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Literature DB >> 2541430

Antibodies specific to the retinoic acid human nuclear receptors alpha and beta.

M P Gaub¹, Y Lutz, E Ruberte, M Petkovich, N Brand, P Chambon.

Abstract

Two cDNAs encoding two human receptors for retinoic acid (RA), RAR-alpha and RAR-beta, have been characterized recently. Synthetic peptides corresponding to the cDNA-deduced amino acid sequences unique to RAR-alpha and RAR-beta were used to generate anti-RAR-alpha antiserum (SP171) and anti-RAR-beta antisera (SP172 and SP248). The specificity of these antisera was confirmed both by immunocytochemical detection of these receptors in COS-1 cells transfected with RAR-alpha and RAR-beta expression vectors and by immunoblot analyses performed with whole extracts of these cells. We also demonstrate that these antisera recognize RAR-alpha and RAR-beta endogenously expressed in the RA-responsive human promyelocytic leukemia cell line HL-60.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2541430 PMCID： PMC287070 DOI： 10.1073/pnas.86.9.3089

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

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Authors: M Petkovich; N J Brand; A Krust; P Chambon
Journal: Nature Date: 1987 Dec 3-9 Impact factor: 49.962

Review 2. An assessment of prediction methods for locating continuous epitopes in proteins.

Authors: M H Van Regenmortel; G Daney de Marcillac
Journal: Immunol Lett Date: 1988-02 Impact factor: 3.685

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Authors: R Lotan
Journal: Biochim Biophys Acta Date: 1980-03-12

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Authors: A Ladoux; E J Cragoe; B Geny; J P Abita; C Frelin
Journal: J Biol Chem Date: 1987-01-15 Impact factor: 5.157

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Authors: D E Ong; J A Crow; F Chytil
Journal: J Biol Chem Date: 1982-11-25 Impact factor: 5.157

6. Expression of granulocytic functions by leukemic promyelocytic HL-60 cells: differential induction by dimethylsulfoxide and retinoic acid.

Authors: Y Matzner; R Gavison; E A Rachmilewitz; E Fibach
Journal: Cell Differ Date: 1987-09

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Authors: A M Jetten; K Anderson; M A Deas; H Kagechika; R Lotan; J I Rearick; K Shudo
Journal: Cancer Res Date: 1987-07-01 Impact factor: 12.701

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Authors: N Brand; M Petkovich; A Krust; P Chambon; H de Thé; A Marchio; P Tiollais; A Dejean
Journal: Nature Date: 1988-04-28 Impact factor: 49.962

9. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

Authors: D Picard; K R Yamamoto
Journal: EMBO J Date: 1987-11 Impact factor: 11.598

10. Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor.

Authors: Y Hashimoto; H Kagechika; E Kawachi; K Shudo
Journal: Jpn J Cancer Res Date: 1988-04

13 in total

1. Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone.

Authors: M Lombès; N Farman; M E Oblin; E E Baulieu; J P Bonvalet; B F Erlanger; J M Gasc
Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

2. Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Authors: F Grignani; U Testa; D Rogaia; P F Ferrucci; P Samoggia; A Pinto; D Aldinucci; V Gelmetti; M Fagioli; M Alcalay; J Seeler; F Grignani; I Nicoletti; C Peschle; P G Pelicci
Journal: EMBO J Date: 1996-09-16 Impact factor: 11.598

3. Immunohistochemical detection of retinoic acid receptor alpha in human skin: a comparison of different fixation protocols.

Authors: S Epple; M Mittmann; J Reichrath
Journal: Histochem J Date: 1996-09

10. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors.

Authors: G Jiang; L Nepomuceno; K Hopkins; F M Sladek
Journal: Mol Cell Biol Date: 1995-09 Impact factor: 4.272