| Literature DB >> 8090764 |
P Gorry1, T Lufkin, A Dierich, C Rochette-Egly, D Décimo, P Dollé, M Mark, B Durand, P Chambon.
Abstract
The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the "hit-and-run" strategy and shown that it prevents the production of a functional CRABPI protein. Homozygous mutant mice were normal, indicating that CRABPI does not play a crucial role in the RA signaling pathway.Entities:
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Year: 1994 PMID： 8090764 PMCID： PMC44741 DOI： 10.1073/pnas.91.19.9032
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205