Lindsay A Rhodes1, Carrie Huisingh1, John Johnstone2, Massimo Fazio1, Brandon Smith1, Mark Clark1, J Crawford Downs1, Cynthia Owsley1, Michael J A Girard3, Jean Martial Mari4, Christopher Girkin1. 1. Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States. 2. Department of Computer and Information Sciences, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States. 3. In Vivo Biomechanics Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 4. Department of Medical Physics and Bioengineering, University College London, London, United Kingdom.
Abstract
PURPOSE: To determine if laminar depth (LD) and prelaminar tissue volume (PTV) are associated with age and race in healthy human eyes. METHODS: Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal eyes from 84 subjects of African descent (AD) and European descent (ED) were manually delineated to identify the principal surfaces: internal limiting membrane, Bruch's membrane (BM), anterior sclera (AS), and anterior surface of the lamina cribrosa. These four surfaces defined the LD and PTV using Bruch's membrane opening (BMO) and AS for reference structures. Generalized estimating equations were used to evaluate whether the effect of age on each outcome was differential by race. RESULTS: When age was analyzed as a continuous variable, the interaction term between age and race was statistically significant for mean LDBMO (P = 0.015) and mean LDAS (P = 0.0062) after adjusting for axial length and BMO area. For every 1-year increase in age, the LDAS was greater on average by 1.78 μm in AD subjects and less by 1.71 μm in ED subjects. Mean PTV was lower in the older subjects (1248 × 10(6) μm(3) AD, 881 × 10(6) μm(3) ED) compared to the younger subjects (1316 × 10(6) μm(3) AD, 1102 × 10(6) μm(3) ED) in both groups. CONCLUSIONS: With increasing age, the LD changes differently across racial groups in normal subjects. The LD in ED subjects showed a significantly decreasing slope suggesting that the lamina moves anteriorly with age in this group. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To determine if laminar depth (LD) and prelaminar tissue volume (PTV) are associated with age and race in healthy human eyes. METHODS: Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal eyes from 84 subjects of African descent (AD) and European descent (ED) were manually delineated to identify the principal surfaces: internal limiting membrane, Bruch's membrane (BM), anterior sclera (AS), and anterior surface of the lamina cribrosa. These four surfaces defined the LD and PTV using Bruch's membrane opening (BMO) and AS for reference structures. Generalized estimating equations were used to evaluate whether the effect of age on each outcome was differential by race. RESULTS: When age was analyzed as a continuous variable, the interaction term between age and race was statistically significant for mean LDBMO (P = 0.015) and mean LDAS (P = 0.0062) after adjusting for axial length and BMO area. For every 1-year increase in age, the LDAS was greater on average by 1.78 μm in AD subjects and less by 1.71 μm in ED subjects. Mean PTV was lower in the older subjects (1248 × 10(6) μm(3) AD, 881 × 10(6) μm(3) ED) compared to the younger subjects (1316 × 10(6) μm(3) AD, 1102 × 10(6) μm(3) ED) in both groups. CONCLUSIONS: With increasing age, the LD changes differently across racial groups in normal subjects. The LD in ED subjects showed a significantly decreasing slope suggesting that the lamina moves anteriorly with age in this group. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Christopher K S Leung; Marco Yu; Robert N Weinreb; Cong Ye; Shu Liu; Gilda Lai; Dennis S C Lam Journal: Ophthalmology Date: 2012-01-20 Impact factor: 12.079
Authors: Christopher A Girkin; Julio E DeLeon-Ortega; Aiyuan Xie; Gerald McGwin; Stella N Arthur; Blythe E Monheit Journal: Ophthalmology Date: 2006-09-25 Impact factor: 12.079
Authors: Hongli Yang; Jingjing Qi; Christy Hardin; Stuart K Gardiner; Nicholas G Strouthidis; Brad Fortune; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2012-01-25 Impact factor: 4.799
Authors: Bryce A Ford; Paul H Artes; Terry A McCormick; Marcelo T Nicolela; Raymond P LeBlanc; Balwantray C Chauhan Journal: Ophthalmology Date: 2003-06 Impact factor: 12.079
Authors: Jae Young You; Sung Chul Park; Daniel Su; Christopher C Teng; Jeffrey M Liebmann; Robert Ritch Journal: JAMA Ophthalmol Date: 2013-03 Impact factor: 7.389
Authors: Brad Fortune; Hongli Yang; Nicholas G Strouthidis; Grant A Cull; Jonathan L Grimm; J Crawford Downs; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2009-05-06 Impact factor: 4.799
Authors: Christopher Bowd; Linda M Zangwill; Robert N Weinreb; Christopher A Girkin; Massimo A Fazio; Jeffrey M Liebmann; Akram Belghith Journal: Am J Ophthalmol Date: 2018-09-07 Impact factor: 5.258
Authors: Ehab A Tamimi; Jeffrey D Pyne; Dominic K Muli; Katelyn F Axman; Stephen J Howerton; Matthew R Davis; Christopher A Girkin; Jonathan P Vande Geest Journal: Invest Ophthalmol Vis Sci Date: 2017-08-01 Impact factor: 4.799
Authors: Linda M Zangwill; Radha Ayyagari; Jeffrey M Liebmann; Christopher A Girkin; Robert Feldman; Harvey Dubiner; Keri A Dirkes; Matthew Holmann; Eunice Williams-Steppe; Naama Hammel; Luke J Saunders; Suzanne Vega; Kevin Sandow; Kathryn Roll; Rigby Slight; Daniel Auerbach; Brian C Samuels; Joseph F Panarelli; John P Mitchell; Lama A Al-Aswad; Sung Chul Park; Celso Tello; Jeremy Cotliar; Rajendra Bansal; Paul A Sidoti; George A Cioffi; Dana Blumberg; Robert Ritch; Nicholas P Bell; Lauren S Blieden; Garvin Davis; Felipe A Medeiros; Maggie C Y Ng; Swapan K Das; Nicholette D Palmer; Jasmin Divers; Carl D Langefeld; Barry I Freedman; Donald W Bowden; Mark A Christopher; Yii-der I Chen; Xiuqing Guo; Kent D Taylor; Jerome I Rotter; Robert N Weinreb Journal: Ophthalmology Date: 2018-02-01 Impact factor: 12.079
Authors: Lindsay A Rhodes; Carrie E Huisingh; Adam E Quinn; Gerald McGwin; Frank LaRussa; Daniel Box; Cynthia Owsley; Christopher A Girkin Journal: Am J Ophthalmol Date: 2016-11-05 Impact factor: 5.258
Authors: John K Johnstone; Lindsay Rhodes; Massimo Fazio; Brandon Smith; Lan Wang; J Crawford Downs; Cynthia Owsley; Christopher A Girkin Journal: Comput Aided Des Appl Date: 2016-03-01