Christopher Bowd1, Linda M Zangwill2, Robert N Weinreb1, Christopher A Girkin3, Massimo A Fazio3, Jeffrey M Liebmann4, Akram Belghith1. 1. Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA. 2. Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA. Electronic address: lzangwill@ucsd.edu. 3. Department of Ophthalmology, University of Alabama, Birmingham, Alabama, USA. 4. Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, USA.
Abstract
PURPOSE: To compare race-related differences in estimated rate of change of Bruch's membrane opening-minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) in healthy, glaucoma suspect, and glaucoma eyes of individuals of European (ED) and African descent (AD). DESIGN: Prospective cohort study. METHODS: This study investigated rate of change of BMO-MRW and RNFLT in 124 healthy, 227 glaucoma suspect, and 177 glaucoma eyes followed for approximately 3 years and tested with optical coherence tomography every 6 months. Suspect eyes had a history of untreated intraocular pressure (IOP) ≥ 22 mm Hg or suspicion of glaucoma by optic disc photograph assessment without repeatable abnormal standard automated perimetry (SAP) results. Glaucoma eyes had repeatable abnormal SAP results (GHT ONL or PSD ≤ 5%). Mixed-effects models were used to estimate the rate of change after controlling for age, mean follow-up IOP, central corneal thickness, axial length, and BMO area. RESULTS: A race-related difference in rate of change of global BMO-MRW but not average RNFLT in suspect eyes was observed. Rate of change of BMO-MRW was -1.82 μm/year and -2.20 μm/year in ED and AD suspect eyes, respectively (P = .03). Rate of change of RNFLT was -0.64 μm/year and -0.75 μm/year in ED and AD suspect eyes, respectively (P = .75). No race-related differences in change rate were found in healthy or glaucoma eyes. CONCLUSION: Race is an important consideration when assessing structural change, particularly minimum rim width, in glaucoma suspect eyes. Differences in rate of structural change may help explain racial disparities in glaucoma susceptibility.
PURPOSE: To compare race-related differences in estimated rate of change of Bruch's membrane opening-minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) in healthy, glaucoma suspect, and glaucoma eyes of individuals of European (ED) and African descent (AD). DESIGN: Prospective cohort study. METHODS: This study investigated rate of change of BMO-MRW and RNFLT in 124 healthy, 227 glaucoma suspect, and 177 glaucoma eyes followed for approximately 3 years and tested with optical coherence tomography every 6 months. Suspect eyes had a history of untreated intraocular pressure (IOP) ≥ 22 mm Hg or suspicion of glaucoma by optic disc photograph assessment without repeatable abnormal standard automated perimetry (SAP) results. Glaucoma eyes had repeatable abnormal SAP results (GHT ONL or PSD ≤ 5%). Mixed-effects models were used to estimate the rate of change after controlling for age, mean follow-up IOP, central corneal thickness, axial length, and BMO area. RESULTS: A race-related difference in rate of change of global BMO-MRW but not average RNFLT in suspect eyes was observed. Rate of change of BMO-MRW was -1.82 μm/year and -2.20 μm/year in ED and AD suspect eyes, respectively (P = .03). Rate of change of RNFLT was -0.64 μm/year and -0.75 μm/year in ED and AD suspect eyes, respectively (P = .75). No race-related differences in change rate were found in healthy or glaucoma eyes. CONCLUSION: Race is an important consideration when assessing structural change, particularly minimum rim width, in glaucoma suspect eyes. Differences in rate of structural change may help explain racial disparities in glaucoma susceptibility.
Authors: Lindsay A Rhodes; Carrie Huisingh; John Johnstone; Massimo Fazio; Brandon Smith; Mark Clark; J Crawford Downs; Cynthia Owsley; Michael J A Girard; Jean Martial Mari; Christopher Girkin Journal: Invest Ophthalmol Vis Sci Date: 2014-11-20 Impact factor: 4.799
Authors: Lindsay A Rhodes; Carrie E Huisingh; Adam E Quinn; Gerald McGwin; Frank LaRussa; Daniel Box; Cynthia Owsley; Christopher A Girkin Journal: Am J Ophthalmol Date: 2016-11-05 Impact factor: 5.258
Authors: Alexandre S C Reis; Glen P Sharpe; Hongli Yang; Marcelo T Nicolela; Claude F Burgoyne; Balwantray C Chauhan Journal: Ophthalmology Date: 2012-01-04 Impact factor: 12.079
Authors: Hussein Antar; Edem Tsikata; Kitiya Ratanawongphaibul; Jing Zhang; Eric Shieh; Ramon Lee; Madeline Freeman; Georgia Papadogeorgou; Huseyin Simavli; Christian Que; Alice C Verticchio Vercellin; Ziad Khoueir; Johannes F de Boer; Teresa C Chen Journal: J Glaucoma Date: 2019-11 Impact factor: 2.503
Authors: Arantxa Acera; Juan Carlos Gómez-Esteban; Ane Murueta-Goyena; Marta Galdos; Mikel Azkargorta; Felix Elortza; Noelia Ruzafa; Oliver Ibarrondo; Xandra Pereiro; Elena Vecino Journal: Proteomes Date: 2022-01-13
Authors: Md Hasnat Ali; Brian Wainwright; Alexander Petersen; Ganesh B Jonnadula; Meghana Desai; Harsha L Rao; M B Srinivas; S Rao Jammalamadaka; Sirisha Senthil; Saumyadipta Pyne Journal: Sci Rep Date: 2021-12-02 Impact factor: 4.379
Authors: Sasan Moghimi; Linda M Zangwill; Huiyuan Hou; Brandon Wong; James Proudfoot; Rafaella C Penteado; Eren Ekici; Christopher Bowd; Robert N Weinreb Journal: Ophthalmol Glaucoma Date: 2020-07-18
Authors: Alessandro A Jammal; Samuel I Berchuck; Atalie C Thompson; Vital P Costa; Felipe A Medeiros Journal: Invest Ophthalmol Vis Sci Date: 2020-11-02 Impact factor: 4.799
Authors: Milica A Margeta; Kitiya Ratanawongphaibul; Edem Tsikata; Michele Zemplenyi; Courtney L Ondeck; Janice Kim; Anne L Coleman; Fei Yu; Johannes F de Boer; Teresa C Chen Journal: Am J Ophthalmol Date: 2021-06-29 Impact factor: 5.258