| Literature DB >> 25403245 |
Muhammad Nawaz1, Giovanni Camussi2, Hadi Valadi3, Irina Nazarenko4, Karin Ekström3, Xiaoqin Wang3, Simona Principe5, Neelam Shah6, Naeem M Ashraf7, Farah Fatima1, Luciano Neder1, Thomas Kislinger5.
Abstract
The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.Entities:
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Year: 2014 PMID： 25403245 DOI： 10.1038/nrurol.2014.301
Source DB: PubMed Journal: Nat Rev Urol ISSN： 1759-4812 Impact factor: 14.432