Literature DB >> 31168963

Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine.

Qi-Ling Yuan1, Yin-Gang Zhang1, Qian Chen2.   

Abstract

Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self-renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC-derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC-derived EVs in regenerative medicine. Anat Rec, 2019.
© 2019 Wiley Periodicals, Inc. © 2019 Wiley Periodicals, Inc.

Entities:  

Keywords:  exosomes; extracellular vesicles; mesenchymal stem cells; regenerative medicine

Mesh：

Year:  2019        PMID： 31168963      PMCID： PMC8327470          DOI： 10.1002/ar.24186

Source DB:  PubMed          Journal:  Anat Rec (Hoboken)        ISSN： 1932-8486            Impact factor:   2.064


  71 in total

1.  Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

Authors:  Maria Francesca Baietti; Zhe Zhang; Eva Mortier; Aurélie Melchior; Gisèle Degeest; Annelies Geeraerts; Ylva Ivarsson; Fabienne Depoortere; Christien Coomans; Elke Vermeiren; Pascale Zimmermann; Guido David
Journal:  Nat Cell Biol       Date:  2012-06-03       Impact factor: 28.824

2.  Isolation and characterization of exosomes from cell culture supernatants and biological fluids.

Authors:  Clotilde Théry; Sebastian Amigorena; Graça Raposo; Aled Clayton
Journal:  Curr Protoc Cell Biol       Date:  2006-04

3.  Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

Authors:  Ruenn Chai Lai; Fatih Arslan; May May Lee; Newman Siu Kwan Sze; Andre Choo; Tian Sheng Chen; Manuel Salto-Tellez; Leo Timmers; Chuen Neng Lee; Reida Menshawe El Oakley; Gerard Pasterkamp; Dominique P V de Kleijn; Sai Kiang Lim
Journal:  Stem Cell Res       Date:  2010-01-04       Impact factor: 2.020

4.  Stem cell-extracellular vesicles as drug delivery systems: New frontiers for silk/curcumin nanoparticles.

Authors:  Sara Perteghella; Barbara Crivelli; Laura Catenacci; Milena Sorrenti; Giovanna Bruni; Vittorio Necchi; Barbara Vigani; Marzio Sorlini; Maria Luisa Torre; Theodora Chlapanidas
Journal:  Int J Pharm       Date:  2017-02-02       Impact factor: 5.875

Review 5.  Proteomics, transcriptomics and lipidomics of exosomes and ectosomes.

Authors:  Dong-Sic Choi; Dae-Kyum Kim; Yoon-Keun Kim; Yong Song Gho
Journal:  Proteomics       Date:  2013-03-12       Impact factor: 3.984

6.  MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.

Authors:  Julie Halkein; Sebastien P Tabruyn; Melanie Ricke-Hoch; Arash Haghikia; Ngoc-Quynh-Nhu Nguyen; Michaela Scherr; Karolien Castermans; Ludovic Malvaux; Vincent Lambert; Marc Thiry; Karen Sliwa; Agnes Noel; Joseph A Martial; Denise Hilfiker-Kleiner; Ingrid Struman
Journal:  J Clin Invest       Date:  2013-04-24       Impact factor: 14.808

7.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

Authors:  Hadi Valadi; Karin Ekström; Apostolos Bossios; Margareta Sjöstrand; James J Lee; Jan O Lötvall
Journal:  Nat Cell Biol       Date:  2007-05-07       Impact factor: 28.824

8.  ExoCarta 2012: database of exosomal proteins, RNA and lipids.

Authors:  Suresh Mathivanan; Cassie J Fahner; Gavin E Reid; Richard J Simpson
Journal:  Nucleic Acids Res       Date:  2011-10-11       Impact factor: 16.971

9.  Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs.

Authors:  Tian Sheng Chen; Ruenn Chai Lai; May May Lee; Andre Boon Hwa Choo; Chuen Neng Lee; Sai Kiang Lim
Journal:  Nucleic Acids Res       Date:  2009-10-22       Impact factor: 16.971

10.  Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts.

Authors:  Li Hu; Juan Wang; Xin Zhou; Zehuan Xiong; Jiajia Zhao; Ran Yu; Fang Huang; Handong Zhang; Lili Chen
Journal:  Sci Rep       Date:  2016-09-12       Impact factor: 4.379
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  6 in total

1.  Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy.

Authors:  Yajun Liu; Qian Chen
Journal:  Curr Mol Biol Rep       Date:  2020-10-28

Review 2.  Potential of Mesenchymal Stem Cell-Derived Exosomes as a Novel Treatment for Female Infertility Caused by Bacterial Infections.

Authors:  Marzieh Zohrabi; Laleh Dehghan Marvast; Mahin Izadi; Seyed Alireza Mousavi; Behrouz Aflatoonian
Journal:  Front Microbiol       Date:  2022-01-27       Impact factor: 5.640

Review 3.  Senescence-Associated Cell Transition and Interaction (SACTAI): A Proposed Mechanism for Tissue Aging, Repair, and Degeneration.

Authors:  Yajun Liu; Jonah Schwam; Qian Chen
Journal:  Cells       Date:  2022-03-24       Impact factor: 6.600

Review 4.  Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration.

Authors:  Kengo Iwasaki; Yihao Peng; Ryuhei Kanda; Makoto Umeda; Isao Ishikawa
Journal:  Int J Mol Sci       Date:  2022-01-18       Impact factor: 5.923

5.  MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing.

Authors:  Guifang Zhao; Feilin Liu; Zinan Liu; Kuiyang Zuo; Bo Wang; Yuying Zhang; Xing Han; Aobo Lian; Yuan Wang; Mingsheng Liu; Fei Zou; Pengdong Li; Xiaomei Liu; Minghua Jin; Jin Yu Liu
Journal:  Stem Cell Res Ther       Date:  2020-05-11       Impact factor: 6.832

6.  The role of hepatocyte growth factor in mesenchymal stem cell-induced recovery in spinal cord injured rats.

Authors:  Peiwen Song; Tianyu Han; Xia Xiang; Ying Wang; Huang Fang; Yang Niu; Cailiang Shen
Journal:  Stem Cell Res Ther       Date:  2020-05-14       Impact factor: 6.832
  6 in total

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