Literature DB >> 2159550

Mutational analysis of simian virus 40 small-t antigen.

P Jog1, B Joshi, V Dhamankar, M J Imperiale, J Rutila, K Rundell.   

Abstract

Several point mutations in the simian virus 40 (SV40) small-t antigen have been analyzed for their effects on protein stability, transformation, transactivation, and binding of two cellular proteins. All mutations which affected cysteine residues in two cysteine clusters produced highly unstable small-t antigens. Four point mutations outside these clusters and one in-frame deletion mutant, dl890, produced stable proteins but reduced transformation efficiency. These were able to transactivate the EII promoter and bind the cellular proteins, suggesting that these activities are not sufficient for small-t-mediated enhancement of transformation.

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Year:  1990        PMID： 2159550      PMCID： PMC249472          DOI： 10.1128/JVI.64.6.2895-2900.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing.

Authors:  G Khoury; P Gruss; R Dhar; C J Lai
Journal:  Cell       Date:  1979-09       Impact factor: 41.582

2.  Amino acid sequence homology between polyoma and SV40 tumour antigens deduced from nucleotide sequences.

Authors:  T Friedmann; R F Doolittle; G Walter
Journal:  Nature       Date:  1978-07-20       Impact factor: 49.962

3.  Nucleotide sequence of the BK virus DNA segment encoding small t antigen.

Authors:  R Dhar; I Seif; G Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

4.  Cellular proteins associated with simian virus 40 early gene products in newly infected cells.

Authors:  Y C Yang; P Hearing; K Rundell
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

5.  Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells.

Authors:  M J Sleigh; W C Topp; R Hanich; J F Sambrook
Journal:  Cell       Date:  1978-05       Impact factor: 41.582

Review 6.  Experimental studies of protein folding and unfolding.

Authors:  T E Creighton
Journal:  Prog Biophys Mol Biol       Date:  1978       Impact factor: 3.667

7.  Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors:  B Hirt
Journal:  J Mol Biol       Date:  1967-06-14       Impact factor: 5.469

8.  Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state.

Authors:  R J Frisque; D B Rifkin; W C Topp
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

9.  The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells.

Authors:  R G Martin; V P Setlow; C A Edwards; D Vembu
Journal:  Cell       Date:  1979-07       Impact factor: 41.582

10.  Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline.

Authors:  K Rundell; J Cox
Journal:  J Virol       Date:  1979-04       Impact factor: 5.103
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  20 in total

1.  Truncated N-terminal mutants of SV40 large T antigen as minimal immortalizing agents for CNS cells.

Authors:  William J Freed; Peisu Zhang; Joseph F Sanchez; Ora Dillon-Carter; Mark Coggiano; Stacie L Errico; Brian D Lewis; Mary Ellen Truckenmiller
Journal:  Exp Neurol       Date:  2005-02       Impact factor: 5.330

Review 2.  Protein phosphatases and DNA tumor viruses: transformation through the back door?

Authors:  M C Mumby; G Walter
Journal:  Cell Regul       Date:  1991-08

3.  A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.

Authors:  A Porrás; J Bennett; A Howe; K Tokos; N Bouck; B Henglein; S Sathyamangalam; B Thimmapaya; K Rundell
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

4.  Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.

Authors:  J Zerrahn; W Deppert
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

5.  JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

Authors:  Brigitte Bollag; Catherine A Hofstetter; Marta M Reviriego-Mendoza; Richard J Frisque
Journal:  PLoS One       Date:  2010-05-12       Impact factor: 3.240

6.  Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen.

Authors:  Ilker K Sariyer; Kamel Khalili; Mahmut Safak
Journal:  Virology       Date:  2008-03-18       Impact factor: 3.616

7.  Multiple, distinct trans-activation functions are encoded by the simian virus 40 large T and small t antigens, only some of which require the 82-residue amino-terminal common domain.

Authors:  M R Loeken
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

8.  Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen.

Authors:  W B Wang; I Bikel; E Marsilio; D Newsome; D M Livingston
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

9.  Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses.

Authors:  B Phillips; K Abravaya; R I Morimoto
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

Review 10.  Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation.

Authors:  Kamel Khalili; Ilker Kudret Sariyer; Mahmut Safak
Journal:  J Cell Physiol       Date:  2008-05       Impact factor: 6.384
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