Katelyn S Kavak1, Barbara E Teter2, Jesper Hagemeier3, Karen Zakalik1, Bianca Weinstock-Guttman4. 1. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, Buffalo, NY, USA/New York State MS Consortium, University at Buffalo, Buffalo, NY, USA. 2. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, Buffalo, NY, USA/New York State MS Consortium, University at Buffalo, Buffalo, NY, USA/Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA. 3. Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA. 4. Jacobs Comprehensive MS Treatment and Research Center, University at Buffalo, Buffalo, NY, USA/New York State MS Consortium, University at Buffalo, Buffalo, NY, USA/Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA bweinstock-guttman@kaleidahealth.org.
Abstract
BACKGROUND: Growing evidence suggests an association between adolescent obesity and increased risk of multiple sclerosis (MS). OBJECTIVE: The objective of this paper is to investigate whether weight or body mass index (BMI) in adolescence and young adulthood was associated with age at MS symptom onset. METHODS: Our cohort is comprised of a sub-group of 184 women enrolled in the New York State MS Consortium registry. Individuals were asked to recall their weight at the time of first menstruation and at age 25. BMI was calculated accordingly for age 25. Regression analyses were carried out to investigate the association between weight or BMI and age at onset. RESULTS: Weight at menarche was significantly related to younger age at symptom onset (β = -0.073, p = 0.001). These results were also found at age 25 for weight (β = -0.080, p < 0.001) and BMI (β = -0.448, p = 0.001). Significantly earlier disease onset (26.9 years ±9.9) was observed in individuals who were overweight at 25 compared to those who were not overweight (32.1 years ±9.2, p = 0.006). CONCLUSIONS: Women who reported higher weight in adolescence and BMI in early adulthood were younger at MS onset. Future research should investigate whether there is a causal link between body weight and MS, as prevention lifestyle and dietary interventions could be implemented.
BACKGROUND: Growing evidence suggests an association between adolescent obesity and increased risk of multiple sclerosis (MS). OBJECTIVE: The objective of this paper is to investigate whether weight or body mass index (BMI) in adolescence and young adulthood was associated with age at MS symptom onset. METHODS: Our cohort is comprised of a sub-group of 184 women enrolled in the New York State MS Consortium registry. Individuals were asked to recall their weight at the time of first menstruation and at age 25. BMI was calculated accordingly for age 25. Regression analyses were carried out to investigate the association between weight or BMI and age at onset. RESULTS: Weight at menarche was significantly related to younger age at symptom onset (β = -0.073, p = 0.001). These results were also found at age 25 for weight (β = -0.080, p < 0.001) and BMI (β = -0.448, p = 0.001). Significantly earlier disease onset (26.9 years ±9.9) was observed in individuals who were overweight at 25 compared to those who were not overweight (32.1 years ±9.2, p = 0.006). CONCLUSIONS:Women who reported higher weight in adolescence and BMI in early adulthood were younger at MS onset. Future research should investigate whether there is a causal link between body weight and MS, as prevention lifestyle and dietary interventions could be implemented.
Authors: P Belov; D Jakimovski; J Krawiecki; C Magnano; J Hagemeier; L Pelizzari; B Weinstock-Guttman; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2017-12-07 Impact factor: 3.825
Authors: Dalia L Rotstein; Marianna Cortese; Teresa T Fung; Tanuja Chitnis; Alberto Ascherio; Kassandra L Munger Journal: Mult Scler Date: 2018-10-23 Impact factor: 6.312
Authors: L Pelizzari; D Jakimovski; M M Laganà; N Bergsland; J Hagemeier; G Baselli; B Weinstock-Guttman; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2018-07-26 Impact factor: 3.825