Thamina Rasul1,2, Jette Lautrup Frederiksen3,4. 1. Department of Neurology, Rigshospitalet-Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark. 2. University of Copenhagen, Copenhagen, Denmark. 3. Department of Neurology, Rigshospitalet-Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark. jette.lautrup.battistini@regionh.dk. 4. University of Copenhagen, Copenhagen, Denmark. jette.lautrup.battistini@regionh.dk.
Abstract
BACKGROUND/AIMS: The prevalence of overweight/obesity is a major problem in the world, and the number of MS cases is increasing. This literature study examines the relationship between overweight/obesity in children and adolescents and later occurrence of MS. METHOD: This is a complete literature survey. The search database is primarily Pubmed using MeSH terms "multiple sclerosis", "obesity", and "overweight", and text words not to restrict searches. RESULTS: All included studies show a link between being overweight/obese and the presence of MS among people below 20 years of age. The relation is especially true for young girls. The same relation in boys is not significant. CONCLUSION: The literature survey convincingly revealed a link between young overweight/obese and occurrence of MS, in particular for girls. There is a need for more and larger studies to investigate the molecular mechanisms that link obesity and MS.
BACKGROUND/AIMS: The prevalence of overweight/obesity is a major problem in the world, and the number of MS cases is increasing. This literature study examines the relationship between overweight/obesity in children and adolescents and later occurrence of MS. METHOD: This is a complete literature survey. The search database is primarily Pubmed using MeSH terms "multiple sclerosis", "obesity", and "overweight", and text words not to restrict searches. RESULTS: All included studies show a link between being overweight/obese and the presence of MS among people below 20 years of age. The relation is especially true for young girls. The same relation in boys is not significant. CONCLUSION: The literature survey convincingly revealed a link between young overweight/obese and occurrence of MS, in particular for girls. There is a need for more and larger studies to investigate the molecular mechanisms that link obesity and MS.
Authors: M Bäärnhielm; A K Hedström; I Kockum; E Sundqvist; S A Gustafsson; J Hillert; T Olsson; L Alfredsson Journal: Eur J Neurol Date: 2012-01-31 Impact factor: 6.089
Authors: Anna Karin Hedström; Izaura Lima Bomfim; Lisa Barcellos; Milena Gianfrancesco; Catherine Schaefer; Ingrid Kockum; Tomas Olsson; Lars Alfredsson Journal: Neurology Date: 2014-02-05 Impact factor: 9.910